Journal article
Oxidants differentially regulate the heat shock response
International journal of hyperthermia, Vol.13(5), pp.517-524
1997
DOI: 10.3109/02656739709023550
PMID: 9354936
Abstract
Cells, animals, and humans respond to hyperthermia through the synthesis of a family of proteins termed heat shock proteins (HSPs). Because hyperthermic stress may also result in mitochondrial uncoupling and the generation of reactive oxygen species, we wondered whether oxidant stress was sufficient to increase cellular levels of HSP70. HSP70 was detected in cells heated or treated with menadione but not in those treated with hydrogen perioxide or xanthine/xanthine oxidase. We speculate that oxidant stress from menadione exposure is qualitatively different from exposure from hydrogen peroxide or xanthine/xanthine oxidase.
Details
- Title: Subtitle
- Oxidants differentially regulate the heat shock response
- Creators
- E. S Wallen - 1Department of Internal Medicine, University of New Mexico, Albuquerque, NM, 87131-5271, USAG. R Buettner - 2The Electron Spin Resonance Facility, University of Iowa, Iowa City, Iowa, 52242, USAP. L Moseley - 1Department of Internal Medicine, University of New Mexico, Albuquerque, NM, 87131-5271, USA
- Resource Type
- Journal article
- Publication Details
- International journal of hyperthermia, Vol.13(5), pp.517-524
- Publisher
- Informa UK Ltd
- DOI
- 10.3109/02656739709023550
- PMID
- 9354936
- ISSN
- 0265-6736
- eISSN
- 1464-5157
- Language
- English
- Date published
- 1997
- Academic Unit
- Radiation Oncology
- Record Identifier
- 9984047768902771
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