Journal article
Oxidation and release of glutathione from myocardium during early reperfusion
Free radical biology & medicine, Vol.7(1), pp.31-35
1989
DOI: 10.1016/0891-5849(89)90097-X
PMID: 2753394
Abstract
Glutathione (GSH) is an important intracellular defense against reactive oxgen metabolites. Reaction of GSH with peroxides generates oxidized glutathione (GSSG). We hypothesized that reperfusion would cause oxidation of GSH and release of GSSG as a potential marker of intracellular oxidative reactions. Ten dogs underwent 90 min left anterior descending (LAD) occlusion and 30 min reperfusion. Coronary sinus (CS) plasma was sampled from the great cardiac vein, which drains the LAD region, and from the aorta at pre-ischemia (I), 90 min ischemia, and during reperfusion (R). We found that both GSSG and GSH increased in coronary sinus plasma during early reperfusion.
Details
- Title: Subtitle
- Oxidation and release of glutathione from myocardium during early reperfusion
- Creators
- Edward J. Lesnefsky - University of Colorado HealthJohn E. Repine - Lung InstituteLawrence D. Horwitz - University of Colorado Health
- Resource Type
- Journal article
- Publication Details
- Free radical biology & medicine, Vol.7(1), pp.31-35
- Publisher
- Elsevier Inc
- DOI
- 10.1016/0891-5849(89)90097-X
- PMID
- 2753394
- ISSN
- 0891-5849
- eISSN
- 1873-4596
- Language
- English
- Date published
- 1989
- Academic Unit
- Cardiovascular Medicine; Internal Medicine
- Record Identifier
- 9984656594202771
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