Oxidation of ferumoxytol by ionizing radiation releases iron. An electron paramagnetic resonance study

Michael S Petronek; Douglas R Spitz; Garry R Buettner; Bryan G Allen

doi:10.1093/jrr/rrac008

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Oxidation of ferumoxytol by ionizing radiation releases iron. An electron paramagnetic resonance study

Journal article

Open access

Peer reviewed

Oxidation of ferumoxytol by ionizing radiation releases iron. An electron paramagnetic resonance study

Michael S Petronek, Douglas R Spitz, Garry R Buettner and Bryan G Allen

Journal of radiation research, Vol.63(3), pp.378-384

03/17/2022

DOI: 10.1093/jrr/rrac008

PMCID: PMC9124617

PMID: 35301531

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9124617View

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Abstract

Ferumoxytol (FMX) is an iron oxide nanoparticle that is FDA approved for the treatment of iron deficiency anemia. FMX contains an Fe 3 O 4 core. Currently, the redox chemistry of Fe 3 O 4 nanoparticles remains relatively unexplored. FMX has recently gained interest as an anti-cancer agent. Ionizing radiation (IR) is a treatment modality employed to treat several types of cancer. Utilizing electron paramagnetic resonance (EPR) spectroscopy, we found that the products produced from the radiolysis of water can oxidize the Fe 3 O 4 core of FMX. Because of the limited diffusion of the HO 2 • and HO • produced, these highly oxidizing species have little direct effect on FMX oxidation. We have determined that H 2 O 2 is the primary oxidant of FMX. In the presence of labile Fe 2+ , we found that reducing species generated from the radiolysis of H 2 O are able to reduce the Fe 3+ sites of the Fe 3 O 4 core. Importantly, we also have shown that IR stimulates the release of ferric iron from FMX. Because of its release of iron, FMX may serve as an adjuvant to enhance radiotherapy.

AcademicSubjects

EPR spectroscopy

ferumoxytol (FMX)

Fricke dosimetry

Fundamental Radiation Science

iron oxide radiolysis

magnetite

MED00870

redox chemistry

SCI00960

Details

Title: Subtitle: Oxidation of ferumoxytol by ionizing radiation releases iron. An electron paramagnetic resonance study
Creators: Michael S Petronek - University of Iowa
Douglas R Spitz - University of Iowa
Garry R Buettner - University of Iowa
Bryan G Allen - University of Iowa
Resource Type: Journal article
Publication Details: Journal of radiation research, Vol.63(3), pp.378-384
DOI: 10.1093/jrr/rrac008
PMID: 35301531
PMCID: PMC9124617
NLM abbreviation: J Radiat Res
ISSN: 0449-3060
eISSN: 1349-9157
Publisher: Oxford University Press
Grant note: P30 CA086862 / ; T32 CA078586; P01 CA217797; P01 CA244091; R01 CA169046; R21 CA256301; G-7-1500 / ;
Language: English
Date published: 03/17/2022
Academic Unit: Pathology; Iowa Neuroscience Institute; Radiation Oncology; Fraternal Order of Eagles Diabetes Research Center
Record Identifier: 9984312966502771

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