Journal article
Oxidative Stress and Cardiovascular Risk in Type 1 Diabetes Mellitus: Insights From the DCCT/EDIC Study
Journal of the American Heart Association, Vol.7(10), p.n/a
05/15/2018
DOI: 10.1161/JAHA.117.008368
PMCID: PMC6015340
Abstract
Background
Hyperglycemia leading to increased oxidative stress is implicated in the increased risk for the development of macrovascular and microvascular complications in patients with type 1 diabetes mellitus.
Methods and Results
A random subcohort of 349 participants was selected from the DCCT/EDIC (Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications) cohort. This included 320 controls and 29 cardiovascular disease cases that were augmented with 98 additional known cases to yield a case cohort of 447 participants (320 controls, 127 cases). Biosamples from DCCT baseline, year 1, and closeout of DCCT, and 1 to 2 years post‐DCCT (EDIC years 1 and 2) were measured for markers of oxidative stress, including plasma myeloperoxidase, paraoxonase activity, urinary F2α isoprostanes, and its metabolite, 2,3 dinor‐8 iso prostaglandin F2α. Following adjustment for glycated hemoblobin and weighting the observations inversely proportional to the sampling selection probabilities, higher paraoxonase activity, reflective of antioxidant activity, and 2,3 dinor‐8 iso prostaglandin F2α, an oxidative marker, were significantly associated with lower risk of cardiovascular disease (−4.5% risk for 10% higher paraoxonase, P<0.003; −5.3% risk for 10% higher 2,3 dinor‐8 iso prostaglandin F2α, P=0.0092). In contrast, the oxidative markers myeloperoxidase and F2α isoprostanes were not significantly associated with cardiovascular disease after adjustment for glycated hemoblobin. There were no significant differences between DCCT intensive and conventional treatment groups in the change in all biomarkers across time segments.
Conclusions
Heightened antioxidant activity (rather than diminished oxidative stress markers) is associated with lower cardiovascular disease risk in type 1 diabetes mellitus, but these biomarkers did not change over time with intensification of glycemic control.
Details
- Title: Subtitle
- Oxidative Stress and Cardiovascular Risk in Type 1 Diabetes Mellitus: Insights From the DCCT/EDIC Study
- Creators
- W.H. Wilson Tang - Cleveland Clinic Cleveland ClinicPaula McGee - George Washington UniversityJohn M Lachin - George Washington UniversityDaniel Y Li - Cleveland ClinicByron Hoogwerf - Cleveland Clinic (Emeritus)Stanley L Hazen - Cleveland Clinic Cleveland ClinicDiabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) Research Group
- Contributors
- L Snetselaar (Contributor) - University of Iowa, Fraternal Order of Eagles Diabetes Research Center
- Resource Type
- Journal article
- Publication Details
- Journal of the American Heart Association, Vol.7(10), p.n/a
- Publisher
- John Wiley and Sons Inc
- DOI
- 10.1161/JAHA.117.008368
- PMCID
- PMC6015340
- ISSN
- 2047-9980
- eISSN
- 2047-9980
- Grant note
- Clinical Translational Science Center Program National Eye Institute National Institutes of Health National Institute of Neurologic Disorders and Stroke U01 DK094176; U01 DK094157 / National Institute of Diabetes and Digestive and Kidney Disease General Clinical Research Centers Program
- Language
- English
- Date published
- 05/15/2018
- Academic Unit
- Epidemiology; Fraternal Order of Eagles Diabetes Research Center; Internal Medicine
- Record Identifier
- 9984215146802771
Metrics
2 Record Views