Oxidative and inflammatory signals in obesity-associated vascular abnormalities

John J Reho; Kamal Rahmouni

doi:10.1042/CS20170219

Back

Oxidative and inflammatory signals in obesity-associated vascular abnormalities

Journal article

Peer reviewed

Oxidative and inflammatory signals in obesity-associated vascular abnormalities

John J Reho and Kamal Rahmouni

Clinical science (1979), Vol.131(14), pp.1689-1700

07/15/2017

DOI: 10.1042/CS20170219

PMID: 28667067

View Online

Abstract

Obesity is associated with increased cardiovascular morbidity and mortality in part due to vascular abnormalities such as endothelial dysfunction and arterial stiffening. The hypertension and other health complications that arise from these vascular defects increase the risk of heart diseases and stroke. Prooxidant and proinflammatory signaling pathways as well as adipocyte-derived factors have emerged as critical mediators of obesity-associated vascular abnormalities. Designing treatments aimed specifically at improving the vascular dysfunction caused by obesity may provide an effective therapeutic approach to prevent the cardiovascular sequelae associated with excessive adiposity. In this review, we discuss the recent evidence supporting the role of oxidative stress and cytokines and inflammatory signals within the vasculature as well as the impact of the surrounding perivascular adipose tissue (PVAT) on the regulation of vascular function and arterial stiffening in obesity. In particular, we focus on the highly plastic nature of the vasculature in response to altered oxidant and inflammatory signaling and highlight how weight management can be an effective therapeutic approach to reduce the oxidative stress and inflammatory signaling and improve vascular function.

Obesity - diet therapy

Cardiovascular Diseases - etiology

Cardiovascular Diseases - physiopathology

Cytokines - metabolism

Obesity - complications

Humans

Oxidative Stress - physiology

Endothelium, Vascular - physiopathology

Obesity - physiopathology

Inflammation - etiology

Animals

Insulin Resistance - physiology

Inflammation Mediators - metabolism

Weight Loss - physiology

Signal Transduction - physiology

Details

Title: Subtitle: Oxidative and inflammatory signals in obesity-associated vascular abnormalities
Creators: John J Reho - Department of Pharmacology, University of Iowa, Iowa City, Iowa, U.S.A
Kamal Rahmouni - Center for Hypertension Research, University of Iowa, Iowa City, Iowa, U.S.A
Resource Type: Journal article
Publication Details: Clinical science (1979), Vol.131(14), pp.1689-1700
DOI: 10.1042/CS20170219
PMID: 28667067
NLM abbreviation: Clin Sci (Lond)
ISSN: 0143-5221
eISSN: 1470-8736
Publisher: England
Grant note: P01 HL084207 / NHLBI NIH HHS
Language: English
Date published: 07/15/2017
Academic Unit: Iowa Neuroscience Institute; Neuroscience and Pharmacology; Internal Medicine
Record Identifier: 9984040267102771

Metrics

15 Record Views

60 Times Cited - Web of Science

See more details