Journal article
Oxidative stress and chromium(VI) carcinogenesis
Journal of environmental pathology, toxicology and oncology, Vol.27(2), pp.77-88
2008
DOI: 10.1615/JEnvironPatholToxicolOncol.v27.i2.10
PMID: 18540844
Abstract
Cr(VI)-containing compounds are known carcinogens that are present in industrial settings and in the environment. The biological mechanisms responsible for the initiation and pregression of diseases resulting from exposure to Cr(VI) are not fully understood. In the last two decades, there has been increasing evidence of the correlation between Cr(VI)-induced generation of reactive oxygen species and carcinogenic actions. This article summarizes the current literature on Cr(VI)-induced generation in various chemical and biological systems. This article also covers the relationship between Cr(VI)-induced oxidative stress and activation of transcription factors NF-kappaB, AP-1, p53, and hypoxia-inducible factor 1, regulation of cell cycle, and induction of apoptosis.
Details
- Title: Subtitle
- Oxidative stress and chromium(VI) carcinogenesis
- Creators
- Hua Yao - University of KentuckyLan Guo - West Virginia UniversityBing-Hua JiangJia Luo - West Virginia UniversityXianglin Shi - University of Kentucky
- Resource Type
- Journal article
- Publication Details
- Journal of environmental pathology, toxicology and oncology, Vol.27(2), pp.77-88
- DOI
- 10.1615/JEnvironPatholToxicolOncol.v27.i2.10
- PMID
- 18540844
- ISSN
- 0731-8898
- eISSN
- 2162-6537
- Grant note
- R01 ES015375 / NIEHS NIH HHS R01 CA119028 / NCI NIH HHS R01 CA116697 / NCI NIH HHS
- Language
- English
- Date published
- 2008
- Academic Unit
- Pathology; Radiation Oncology
- Record Identifier
- 9984186489902771
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