Oxidative stress and immune cell activation quantification in sepsis and non-sepsis critical care patients by neopterin/7,8-dihydroneopterin analysis

Gregory Baxter-Parker; Ravinder Reddy Gaddam; Elena Moltchanova; Anitra Carr; Geoff Shaw; Stephen Chambers; Steven P Gieseg

doi:10.1515/pteridines-2020-0015

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Oxidative stress and immune cell activation quantification in sepsis and non-sepsis critical care patients by neopterin/7,8-dihydroneopterin analysis

Journal article

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Oxidative stress and immune cell activation quantification in sepsis and non-sepsis critical care patients by neopterin/7,8-dihydroneopterin analysis

Gregory Baxter-Parker, Ravinder Reddy Gaddam, Elena Moltchanova, Anitra Carr, Geoff Shaw, Stephen Chambers and Steven P Gieseg

Pteridines, Vol.31(1), pp.68-82

05/29/2020

DOI: 10.1515/pteridines-2020-0015

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Abstract

Introduction: Neopterin and 7,8-dihydroneopterin are used as biomarkers of oxidative stress and inflammation, but the effect of kidney function on these measurements has not been extensively explored. We examine the levels of oxidative stress, inflammation and kidney function in intensive patients and compare them to equivalent patients without sepsis. Methods: 34 Intensive care patients were selected for the study, 14 without sepsis and 20 with. Both groups had equivalent levels of trauma, assessed by SAPS II, SOFA, and APACHE II and III scores. Plasma and urinary neopterin and total neopterin (neopterin + 7,8-dihydroneopterin) values were measured. Results: Neopterin and total neopterin were significantly elevated in urine and plasma for multiple days in sepsis versus non-sepsis patients. Plasma neopterin and total neopterin have decreasing relationships with increased eGFR (p<0.008 and p<0.001, respectively). Plasma/urinary neopterin and total neopterin ratios demonstrate that total neopterin flux is more influenced by eGFR than neopterin, with significantce of p<0.02 and p<0.0002 respectively. Conclusion: Sepsis patients present with greater levels of oxidative stress and immune system activation than non-sepsis patients of equal levels of trauma, as measured by neopterin and total neopterin. eGFR may need to be taken into account when accessing the level of inflammation from urinary neopterin measurements.

Inflammation

Biomarkers

Sepsis

kidney function

neopterin

7,8-dihydroneopterin

Details

Title: Subtitle: Oxidative stress and immune cell activation quantification in sepsis and non-sepsis critical care patients by neopterin/7,8-dihydroneopterin analysis
Creators: Gregory Baxter-Parker - School of Biological Sciences, University of Canterbury, Christchurch, New Zealand
Ravinder Reddy Gaddam - Division of Cardiovascular Medicine, Department of Internal Medicine, Abboud Cardiovascular Research Center, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA
Elena Moltchanova - Department of Mathematics and Statistics, University of Canterbury, Christchurch, New Zealand
Anitra Carr - Department of Pathology & Biomedical Science, University of Otago Christchurch, Christchurch, New Zealand
Geoff Shaw - Department of Intensive Care, Christchurch Hospital, New Zealand
Stephen Chambers - Department of Pathology & Biomedical Science, University of Otago Christchurch, Christchurch, New Zealand
Steven P Gieseg - School of Biological Sciences, University of Canterbury, Christchurch, New Zealand
Resource Type: Journal article
Publication Details: Pteridines, Vol.31(1), pp.68-82
DOI: 10.1515/pteridines-2020-0015
ISSN: 0933-4807
eISSN: 2195-4720
Publisher: De Gruyter
Number of pages: 15
Language: English
Date published: 05/29/2020
Academic Unit: Internal Medicine
Record Identifier: 9984066111502771

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