Journal article
Oxidized Activated Charcoal Nanozymes: Synthesis, and Optimization for In Vitro and In Vivo Bioactivity for Traumatic Brain Injury
Advanced materials (Weinheim), Vol.36(10), pp.e2211239-n/a
03/01/2024
DOI: 10.1002/adma.202211239
PMCID: PMC10509328
PMID: 36940058
Abstract
Carbon-based superoxide dismutase (SOD) mimetic nanozymes have recently been employed as promising antioxidant nanotherapeutics due to their distinct properties. The structural features responsible for the efficacy of these nanomaterials as antioxidants are, however, poorly understood. Here, the process-structure-property-performance properties of coconut-derived oxidized activated charcoal (cOAC) nano-SOD mimetics are studied by analyzing how modifications to the nanomaterial's synthesis impact the size, as well as the elemental and electrochemical properties of the particles. These properties are then correlated to the in vitro antioxidant bioactivity of poly(ethylene glycol)-functionalized cOACs (PEG-cOAC). Chemical oxidative treatment methods that afford smaller, more homogeneous cOAC nanoparticles with higher levels of quinone functionalization show enhanced protection against oxidative damage in bEnd.3 murine endothelioma cells. In an in vivo rat model of mild traumatic brain injury (mTBI) and oxidative vascular injury, PEG-cOACs restore cerebral perfusion rapidly to the same extent as the former nanotube-derived PEG-hydrophilic carbon clusters (PEG-HCCs) with a single intravenous injection. These findings provide a deeper understanding of how carbon nanozyme syntheses can be tailored for improved antioxidant bioactivity, and set the stage for translation of medical applications.
Details
- Title: Subtitle
- Oxidized Activated Charcoal Nanozymes: Synthesis, and Optimization for In Vitro and In Vivo Bioactivity for Traumatic Brain Injury
- Creators
- Emily A. McHugh - Rice UniversityAnton V. Liopo - Texas A&M Health Science CenterKimberly Mendoza - Rice UniversityClaudia S. Robertson - Baylor College of MedicineGang Wu - The University of Texas Health Science Center at HoustonZhe Wang - Rice UniversityWeiyin Chen - Rice UniversityJacob L. Beckham - Rice UniversityPaul J. Derry - Texas A&M Health Science CenterThomas A. Kent - Rice UniversityJames M. Tour - Rice University
- Resource Type
- Journal article
- Publication Details
- Advanced materials (Weinheim), Vol.36(10), pp.e2211239-n/a
- Publisher
- Wiley
- DOI
- 10.1002/adma.202211239
- PMID
- 36940058
- PMCID
- PMC10509328
- ISSN
- 0935-9648
- eISSN
- 1521-4095
- Number of pages
- 16
- Grant note
- R21NS084290; R01NS094535 / NIH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA BE-0048 / Welch Foundation; The Welch Foundation
- Language
- English
- Date published
- 03/01/2024
- Academic Unit
- Chemical and Biochemical Engineering
- Record Identifier
- 9984696802102771
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