Journal article
Oxygen and Carbon Dioxide Regulation of Toxic Shock Syndrome Toxin 1 Production by Staphylococcus aureus MN8
Journal of clinical microbiology, Vol.38(5), pp.1797-1803
05/2000
DOI: 10.1128/JCM.38.5.1797-1803.2000
PMCID: PMC86591
PMID: 10790102
Abstract
The production of toxic shock syndrome toxin 1 (TSST-1) by
Staphylococcus aureus
MN8 exposed to a range of oxygen concentrations (0 to 21% [vol/vol]) was examined in batch and thin-film cultures. The response of
S. aureus
to this range of oxygen concentrations was studied in the absence and in the presence of 7% (vol/vol) carbon dioxide. In the absence of carbon dioxide, TSST-1 production in batch cultures increased from negligible levels in the presence of oxygen concentrations of 1% or less to 500 ng/ml in the presence of 2% oxygen and then decreased to 70 ng/ml or less in the presence of oxygen concentrations of 6% and higher. In the presence of carbon dioxide, however, toxin production increased from negligible levels in the presence of 1% oxygen to 1,900 ng/ml in the presence of 21% oxygen. In thin-film cultures, TSST-1 production increased from nearly undetectable levels under anaerobic conditions to 1 and 10 μg/ml under 21% oxygen in the absence and presence of carbon dioxide, respectively. This study demonstrates the controlling effects of both oxygen and carbon dioxide on TSST-1 production.
Details
- Title: Subtitle
- Oxygen and Carbon Dioxide Regulation of Toxic Shock Syndrome Toxin 1 Production by Staphylococcus aureus MN8
- Creators
- Jeremy M Yarwood - Department of Microbiology, University of Minnesota Medical School, Minneapolis, Minnesota 55455Patrick M Schlievert - Department of Microbiology, University of Minnesota Medical School, Minneapolis, Minnesota 55455
- Resource Type
- Journal article
- Publication Details
- Journal of clinical microbiology, Vol.38(5), pp.1797-1803
- Publisher
- American Society for Microbiology
- DOI
- 10.1128/JCM.38.5.1797-1803.2000
- PMID
- 10790102
- PMCID
- PMC86591
- ISSN
- 0095-1137
- eISSN
- 1098-660X
- Language
- English
- Date published
- 05/2000
- Academic Unit
- Microbiology and Immunology; Internal Medicine
- Record Identifier
- 9984001111102771
Metrics
29 Record Views