Journal article
Oxygen transport to tissue by persistent bubbles: theory and simulations
Journal of applied physiology (1985), Vol.77(6), pp.2874-2878
12/01/1994
DOI: 10.1152/jappl.1994.77.6.2874
PMID: 7896635
Abstract
Persistent gas bubbles able to traverse capillaries can be prepared from a slowly permeating gas or with a mechanical structure surrounding a gas phase. If they are permeable to gases, such bubbles will carry O2 from the lungs to the tissues via the blood stream. Using a mathematical model based on physical laws, we present simulations of the behavior of bubbles stabilized by a slowly permeating gas (gas X). We show that the bubble persists longer if the tissue and venous blood contain N2 to dilute gas X and slow its outward diffusion. A 6-microns -diam bubble carries 0.11 pl of O2 during the breathing of pure O2, so 4.6 x 10(8) bubbles/ml in the blood will supply a normal arteriovenous difference. In conditions used for hyperbaric O2 therapy, a bubble carries approximately 0.26 pl of O2. Stabilized bubbles have the potential to transport O2 efficiently; they release O2 to tissue at high PO2 and require injection of only small amounts of a foreign substance.
Details
- Title: Subtitle
- Oxygen transport to tissue by persistent bubbles: theory and simulations
- Creators
- Mark E Burkard - Department of Physiology, State University of New York, Buffalo 14214Hugh D Van Liew - Department of Physiology, State University of New York, Buffalo 14214
- Resource Type
- Journal article
- Publication Details
- Journal of applied physiology (1985), Vol.77(6), pp.2874-2878
- DOI
- 10.1152/jappl.1994.77.6.2874
- PMID
- 7896635
- NLM abbreviation
- J Appl Physiol (1985)
- ISSN
- 8750-7587
- eISSN
- 1522-1601
- Number of pages
- 5
- Language
- English
- Date published
- 12/01/1994
- Academic Unit
- Internal Medicine
- Record Identifier
- 9984701254802771
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