Journal article
Oxygen‐enhanced 3D radial ultrashort echo time magnetic resonance imaging in the healthy human lung
NMR in biomedicine, Vol.27(12), pp.1535-1541
12/2014
DOI: 10.1002/nbm.3158
PMCID: PMC4233000
PMID: 24984695
Abstract
The purpose of this work was to use 3D radial ultrashort echo time (UTE) MRI to perform whole‐lung oxygen‐enhanced (OE) imaging in humans.
Eight healthy human subjects underwent two 3D radial UTE MRI acquisitions (TE = 0.08 ms): one while breathing 21% O2 and the other while breathing 100% O2. Scans were each performed over 5 min of free breathing, using prospective respiratory gating. For comparison purposes, conventional echo time (TE = 2.1 ms) images were acquired simultaneously during each acquisition using a radial " outward‐inward" k‐space trajectory. 3D percent OE maps were generated from these images.
3D OE maps showing lung signal enhancement were generated successfully in seven subjects (technical failure in one subject). Mean percent signal enhancement was 6.6% ± 1.8%, near the value predicted by theory of 6.3%. No significant enhancement was seen using the conventional echo time data, confirming the importance of UTE for this acquisition strategy.
3D radial UTE MRI shows promise as a method for OE MRI that enables whole‐lung coverage and isotropic spatial resolution, in comparison to existing 2D OE methods, which rely on a less time‐efficient inversion recovery pulse sequence. These qualities may help OE MRI become a viable low‐cost method for 3D imaging of lung function in human subjects. Copyright © 2014 John Wiley & Sons, Ltd.
To evaluate the efficacy of 3D radial ultrashort echo time MRI to perform whole‐lung oxygen‐enhanced ventilation imaging in humans, two isotropic 3D radial acquisitions were performed at respiration of 21% O2 and 100% O2 respectively. Percent oxygen enhancement maps were generated from these images. Mean percent signal enhancement was 6.6% ± 1.8%, near the value predicted by theory. 3D radial UTE MRI shows promise as a method for oxygen‐enhanced MRI that enables whole‐lung coverage and isotropic spatial resolution.
Details
- Title: Subtitle
- Oxygen‐enhanced 3D radial ultrashort echo time magnetic resonance imaging in the healthy human lung
- Creators
- Stanley J Kruger - University of Wisconsin–MadisonSean B Fain - University of Wisconsin–MadisonKevin M Johnson - University of Wisconsin–MadisonRobert V Cadman - University of Wisconsin–MadisonScott K Nagle - University of Wisconsin–Madison
- Resource Type
- Journal article
- Publication Details
- NMR in biomedicine, Vol.27(12), pp.1535-1541
- DOI
- 10.1002/nbm.3158
- PMID
- 24984695
- PMCID
- PMC4233000
- NLM abbreviation
- NMR Biomed
- ISSN
- 0952-3480
- eISSN
- 1099-1492
- Publisher
- Wiley
- Number of pages
- 7
- Grant note
- University of Wisconsin Department of Radiology R&D Committee, The Hartwell Foundation, the UW School of Medicine and Public Health from the Wisconsin Partnership Program, the UW Graduate School, the Clinical and Translational Science Award (CTSA) program (1UL1RR025011; 9U54TR000021; NIH/NHLBI U10 HL109168; P01 HL070831)
- Language
- English
- Date published
- 12/2014
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Radiology; Electrical and Computer Engineering; Iowa Neuroscience Institute; Health, Sport, and Human Physiology
- Record Identifier
- 9984051579102771
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