P-505: Regional variation in leptin-induced sympathoactivation in agouti obese mice

Kamal Rahmouni; William G Haynes; Donald A Morgan; Gina M Morgan; Marcelo L.G Correia; Allyn L Mark

doi:10.1016/j.amjhyper.2004.03.579

Back

P-505: Regional variation in leptin-induced sympathoactivation in agouti obese mice

Journal article

Open access

Peer reviewed

P-505: Regional variation in leptin-induced sympathoactivation in agouti obese mice

Kamal Rahmouni, William G Haynes, Donald A Morgan, Gina M Morgan, Marcelo L.G Correia and Allyn L Mark

American journal of hypertension, Vol.17(S1), pp.217A-217A

05/2004

DOI: 10.1016/j.amjhyper.2004.03.579

Files and links (1)

url

https://doi.org/10.1016/j.amjhyper.2004.03.579View

Published (Version of record) Open Access

Abstract

We have previously demonstrated that in agouti obese mice there is selective resistance to leptin with preservation of the renal sympathetic nerve activity (SNA) response to leptin despite loss of the feeding- and weight-reducing effects of leptin. Because only the renal SNA response to leptin was examined in these studies, it was not clear if leptin-induced sympathoactivation to other beds was preserved or lost in this model of obesity with leptin resistance. In this study, we tested the hypothesis that in agouti obese mice while the renal SNA response to leptin is preserved, the SNA response to other beds may be impaired. For this, we compared the brown adipose tissue (BAT) and lumbar SNA responses to intravenous administration of vehicle and leptin (60 and 120 μg) in anesthetized lean and agouti obese mice. In lean mice, intravenous administration of leptin caused a dose-dependent rise in both BAT and lumbar SNA. Leptin (120 μg) increased BAT and lumbar SNA by 187±37% (n=8, P<0.001 vs. vehicle) and 100±31 (n=8, P<0.001), respectively. In contrast, agouti obese mice had a significantly attenuated (P<0.05 vs. lean mice) BAT and lumbar sympathoactivation to leptin. In these obese mice, 120 μg of leptin increased BAT and lumbar SNA by only 84±29% (n=8) and 4±24% (n=8), respectively. Preservation of leptin-induced sympathoactivation in agouti obese mice appears to be specific to the renal SNA because the BAT and lumbar SNA are resistant to leptin in this model of obesity. Loss of thermogenic sympathoactivation to leptin may promote obesity while preservation of renal sympathoactivation to leptin in presence of hyperleptinemia may promote hypertension. Am J Hypertens (2004) 17, 217A–217A; doi: 10.1016/j.amjhyper.2004.03.579

Hypertension

sympathetic Nerve Activity

Leptin resistance

Details

Title: Subtitle: P-505: Regional variation in leptin-induced sympathoactivation in agouti obese mice
Creators: Kamal Rahmouni - Hypertension Genetics SCOR, CV Center and Department of Internal Medicine, University of Iowa, Iowa City, IA, USA
William G Haynes - Hypertension Genetics SCOR, CV Center and Department of Internal Medicine, University of Iowa, Iowa City, IA, USA
Donald A Morgan - Hypertension Genetics SCOR, CV Center and Department of Internal Medicine, University of Iowa, Iowa City, IA, USA
Gina M Morgan - Hypertension Genetics SCOR, CV Center and Department of Internal Medicine, University of Iowa, Iowa City, IA, USA
Marcelo L.G Correia - Hypertension Genetics SCOR, CV Center and Department of Internal Medicine, University of Iowa, Iowa City, IA, USA
Allyn L Mark - Hypertension Genetics SCOR, CV Center and Department of Internal Medicine, University of Iowa, Iowa City, IA, USA
Resource Type: Journal article
Publication Details: American journal of hypertension, Vol.17(S1), pp.217A-217A
DOI: 10.1016/j.amjhyper.2004.03.579
ISSN: 0895-7061
eISSN: 1879-1905
Publisher: Oxford University Press
Language: English
Date published: 05/2004
Academic Unit: Iowa Neuroscience Institute; Neuroscience and Pharmacology; Endocrinology and Metabolism; Internal Medicine
Record Identifier: 9984071949802771

Metrics

19 Record Views