Journal article
P-glycoprotein in human sarcoma: evidence for multidrug resistance
Journal of clinical oncology, Vol.5(9), pp.1452-1460
09/01/1987
DOI: 10.1200/JCO.1987.5.9.1452
PMID: 2887642
Abstract
Overexpression of an immunologically conserved, cell-surface glycoprotein (P-glycoprotein) is consistently associated with multidrug resistance in cell lines in vitro. A preliminary survey of specimens from 12 solid tumor types in our laboratories indicates significant overexpression of P-glycoprotein in some sarcomas. When tested by immunoblotting with monoclonal antibodies directed against P-glycoprotein; tumors from six of 25 sarcoma patients displayed elevated levels of P-glycoprotein. Three of the sarcoma patients exhibiting P-glycoprotein had not previously been exposed to chemotherapy, implying that overexpression of this marker and possible concomitant multidrug resistance may not depend only on selection during prior drug treatments. The P-glycoprotein overexpression in the sarcoma specimens is evidence for the presence of multidrug resistant cells in these tumors; thus, our data suggest that this mode of resistance may have clinical significance in sarcoma patients.
Details
- Title: Subtitle
- P-glycoprotein in human sarcoma: evidence for multidrug resistance
- Creators
- J H GerlachD R BellC KarakousisH K SlocumN KartnerY M RustumV LingR M Baker
- Resource Type
- Journal article
- Publication Details
- Journal of clinical oncology, Vol.5(9), pp.1452-1460
- DOI
- 10.1200/JCO.1987.5.9.1452
- PMID
- 2887642
- ISSN
- 0732-183X
- eISSN
- 1527-7755
- Language
- English
- Date published
- 09/01/1987
- Academic Unit
- Hematology, Oncology, and Blood & Marrow Transplantation; Internal Medicine
- Record Identifier
- 9984360038702771
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