Journal article
P2Y12 Inhibitors versus Aspirin Monotherapy for Long-term Secondary Prevention of Atherosclerotic Cardiovascular Disease Events: A Systematic Review and Meta-analysis
Current problems in cardiology, Vol.47(10), pp.101292-101292
10/2022
DOI: 10.1016/j.cpcardiol.2022.101292
PMID: 35764143
Abstract
Patients with established atherosclerotic cardiovascular disease (ASCVD) need long-term antiplatelet therapy to decrease the risk of future ASCVD events. We searched PubMed, Cochrane Library, and ClinicalTrials.gov (inception through September 2021) for randomized controlled trials (RCTs) evaluating P2Y
inhibitors vs aspirin for secondary prevention of ASCVD events. Seven RCTs including a total of 56,982 patients were included in this analysis. The median follow-up duration was 22.8 (IQR 12) months. When P2Y
inhibitors were compared with aspirin as long-term antiplatelet therapy for secondary prevention of ASCVD events, there was a significant decrease in the risk of myocardial infarction [RR: 0.83; 95% CI: 0.72-0.94], and stroke [RR: 0.90; 95% CI: 0.83-0.99]. However, there was no significant difference in all-cause mortality [RR: 1.02; 95% CI: 0.92-1.12], or cardiovascular mortality [RR: 0.95; 95% CI: 0.83-1.08] between P2Y
inhibitors and aspirin users. Additionally, there was no significant difference in major bleeding events [RR: 0.88; 95% CI: 0.74-1.04], or all bleeding events [RR: 1.09; 95% CI: 0.90-1.33] between P2Y
inhibitors and aspirin groups. Use of P2Y
inhibitor monotherapy is associated with lower rates of myocardial infarction and stroke in ASCVD patients without any significant difference in mortality, or bleeding compared to aspirin monotherapy.
Details
- Title: Subtitle
- P2Y12 Inhibitors versus Aspirin Monotherapy for Long-term Secondary Prevention of Atherosclerotic Cardiovascular Disease Events: A Systematic Review and Meta-analysis
- Creators
- Ahmad Al-Abdouh - University of KentuckyWaiel Abusnina - Creighton UniversityMohammed Mhanna - University of ToledoQais Radideh - Creighton UniversityHossam Alzu'bi - Mayo ClinicAnan Abu Rmilah - Mayo ClinicAhmad Jabri - MetroHealth Medical CenterMahmoud Barbarawi - University of ConnecticutKhaldun Obeidat - John H. Stroger, Jr. Hospital of Cook CountyTaqwa Alabduh - Yarmouk UniversityErin D Michos - Johns Hopkins UniversityTalal Alnabelsi - University of KentuckyTimir K Paul - University of Tennessee at Knoxville
- Resource Type
- Journal article
- Publication Details
- Current problems in cardiology, Vol.47(10), pp.101292-101292
- DOI
- 10.1016/j.cpcardiol.2022.101292
- PMID
- 35764143
- NLM abbreviation
- Curr Probl Cardiol
- ISSN
- 0146-2806
- eISSN
- 1535-6280
- Language
- English
- Date published
- 10/2022
- Academic Unit
- Internal Medicine
- Record Identifier
- 9984845249802771
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