Journal article
PAX2 in human kidney malformations and disease
Pediatric nephrology (Berlin, West), Vol.27(8), pp.1265-1275
08/2012
DOI: 10.1007/s00467-011-2053-0
PMID: 22138676
Abstract
Human PAX2 mutations have been associated with abnormalities in the developing and adult kidney ranging from congenital abnormalities of the kidney and urinary tract (CAKUT) to oncogenic processes. Defining the relationship of PAX2 to human renal disease requires an appreciation of its fundamental role in renal development. Given the highly conserved nature of the PAX2 gene in vertebrates, it is not surprising that much of our understanding of PAX2 involvement in renal disease has been derived from animal models. The following review will outline the current evidence supporting involvement of PAX2 in the pathologic processes involving the kidney.
Details
- Title: Subtitle
- PAX2 in human kidney malformations and disease
- Creators
- Lyndsay A Harshman - Department of Pediatrics, Division of Nephrology, Dialysis & Transplantation, University of Iowa Carver College of Medicine, Iowa City, IA, USAPatrick D Brophy
- Resource Type
- Journal article
- Publication Details
- Pediatric nephrology (Berlin, West), Vol.27(8), pp.1265-1275
- Publisher
- Germany
- DOI
- 10.1007/s00467-011-2053-0
- PMID
- 22138676
- ISSN
- 0931-041X
- eISSN
- 1432-198X
- Language
- English
- Date published
- 08/2012
- Academic Unit
- Nephrology, Dialysis and Transplantation; Stead Family Department of Pediatrics; Iowa Neuroscience Institute
- Record Identifier
- 9984065488802771
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