Journal article
PBRM1 Regulates Stress Response in Epithelial Cells
iScience, Vol.15, pp.196-210
05/31/2019
DOI: 10.1016/j.isci.2019.04.027
PMCID: PMC6514269
PMID: 31077944
Abstract
Polybromo1 (PBRM1) is a chromatin remodeler subunit highly mutated in cancer, particularly clear cell renal carcinoma. PBRM1 is a member of the SWI/SNF subcomplex, PBAF (PBRM1-Brg1/Brm-associated factors), and is characterized by six tandem bromodomains. Here we establish a role for PBRM1 in epithelial cell maintenance through the expression of genes involved in cell adhesion, metabolism, stress response, and apoptosis. In support of a general role for PBRM1 in stress response and apoptosis, we observe that loss of PBRM1 results in an increase in reactive oxygen species generation and a decrease in cellular viability under stress conditions. We find that loss of PBRM1 promotes cell growth under favorable conditions but is required for cell survival under conditions of cellular stress.
Details
- Title: Subtitle
- PBRM1 Regulates Stress Response in Epithelial Cells
- Creators
- Elizabeth G. Porter - Purdue University West LafayetteAlisha Dhiman - Purdue University West LafayetteBasudev Chowdhury - Purdue University West LafayetteBenjamin C. Carter - Purdue University West LafayetteHang Lin - Purdue University West LafayetteJane C. Stewart - Purdue University West LafayetteMajid Kazemian - Purdue University West LafayetteMichael K. Wendt - Purdue University West LafayetteEmily C. Dykhuizen - Purdue University West Lafayette
- Resource Type
- Journal article
- Publication Details
- iScience, Vol.15, pp.196-210
- DOI
- 10.1016/j.isci.2019.04.027
- PMID
- 31077944
- PMCID
- PMC6514269
- NLM abbreviation
- iScience
- ISSN
- 2589-0042
- eISSN
- 2589-0042
- Publisher
- Elsevier
- Number of pages
- 29
- Grant note
- K22HL125593 / NATIONAL HEART, LUNG, AND BLOOD INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI) V2014-004; D2016-030 / V Foundation for Cancer Research U01CA207532; R01CA207751; K22HL125593 / NIH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA P30CA023168 / NATIONAL CANCER INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI) P30 CA023168 / Purdue University Center for Cancer Research, NIH W81XWH-17-1-0267 / Office of the Assistant Secretary of Defense for Health Affairs, through the Peer Reviewed Cancer Research Program Borch Graduate Fellowship from the Purdue Department of Medicinal Chemistry and Molecular Pharmacology
- Language
- English
- Date published
- 05/31/2019
- Academic Unit
- Internal Medicine
- Record Identifier
- 9984459633002771
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