Journal article
PCBs and OH-PCBs in serum from children and mothers in urban and rural U.S. communities
Environmental science & technology, Vol.47(7), pp.3353-3361
04/02/2013
DOI: 10.1021/es304455k
PMCID: PMC3645264
PMID: 23452180
Abstract
East Chicago, Indiana is a heavily industrialized community bisected by the Indiana Harbor and Ship Canal, which volatilizes ~7.5 kg/yr polychlorinated biphenyls (PCBs). In contrast, the rural Columbus Junction, Iowa area has no known current or past PCB industrial sources. Blood from children and their mothers from these communities were collected April 2008 to January 2009 (n = 177). Sera were analyzed for all 209 PCBs and 4 hydroxylated PCBs (OH-PCBs). Sum PCBs ranged from nondetect to 658 ng/g lw (median = 33.5 ng/g lw). Sum OH-PCBs ranged from nondetect to 1.2 ng/g fw (median = 0.07 ng/g fw). These concentrations are similar to those reported in other populations without high dietary PCB intake. Differences between the two communities were subtle. PCBs were detected in more East Chicago mothers and children than Columbus Junction mothers and children, and children from East Chicago were enriched in lower-molecular weight PCBs. East Chicago and Columbus Junction residents had similar levels of total and individual PCBs and OH-PCBs in their blood. Concentrations of parent PCBs correlated with concentrations of OH-PCBs. This is the first temporally and methodologically consistent study to evaluate all 209 PCBs and major metabolites in two generations of people living in urban and rural areas of the United States.
Details
- Title: Subtitle
- PCBs and OH-PCBs in serum from children and mothers in urban and rural U.S. communities
- Creators
- Rachel F Marek - Department of Civil & Environmental Engineering, The University of Iowa, Iowa City, Iowa 52242, United StatesPeter S ThorneKai WangJeanne DewallKeri C Hornbuckle
- Resource Type
- Journal article
- Publication Details
- Environmental science & technology, Vol.47(7), pp.3353-3361
- DOI
- 10.1021/es304455k
- PMID
- 23452180
- PMCID
- PMC3645264
- NLM abbreviation
- Environ Sci Technol
- ISSN
- 0013-936X
- eISSN
- 1520-5851
- Publisher
- United States
- Grant note
- P42 ES013661 / NIEHS NIH HHS P30 ES005605 / NIEHS NIH HHS NIH P42 ES013661 / NIEHS NIH HHS
- Language
- English
- Date published
- 04/02/2013
- Academic Unit
- Civil and Environmental Engineering; Occupational and Environmental Health; Biostatistics; IIHR--Hydroscience and Engineering; Iowa Superfund Research Program
- Record Identifier
- 9983997463402771
Metrics
22 Record Views