Journal article
PCBs and PBBs: Biologic and toxic effects on C57BL/6J and DBA/2J inbred mice
Toxicology (Amsterdam), Vol.31(3), pp.191-206
1984
DOI: 10.1016/0300-483X(84)90101-X
PMID: 6330936
Abstract
Treatment of genetically inbred “responsive” C57BL/6J and ”non-responsive” DBA/2J mice with Aroclor 1254 or fireMaster BP-6 resulted in the induction of hepatic microsomal benzo[
a]pyrene hydroxylase only in the former mouse strain and aminopyrine
N-demethylase in both strains of mice. In contrast, 3,3′,4,4′,5-pentachlorobiphenyl and 3,3′,4,4′-tetrabromobiphenyl, induced benzo[
a]pyrene hydroxylase in both C57BL/6J and DBA/2J but did not enhance aminopyrine
N-demethylase in either strain of mouse. Boo these coplanar halogenated biphenyls also caused thymic atrophy in the responsive and non-responsive mice and their effects resembled those of 2,3,7,8-tetrachlorodibenzo-
p-dioxin (TCDD). Treatment of the inbred mice with several mono-
ortho substituted analogs of the coplanar halogenated biphenyls, including 2,3,3′,4,4′-pentachloro-, 2,3′,4,4′,5-pentabromo, 2,3,3′,4,4′,5-hexachloro- and 3′,4′-dibromo-2,3,4,5-tetrachlorobiphenyl, gave hepatic enzyme-induction results similar to those observed for the commercial halogenated biphenyls. At dose levels of 1500 μmol/kg, most of these compounds caused thymic atrophy in C57BL/6J mice but not in DBA/2J mice. The structure-activity correlations in the mice complement similar studies with the halogenated biphenyls in rats and support the proposed receptor-mediated mechanism for the toxic halogenated aromatics.
Details
- Title: Subtitle
- PCBs and PBBs: Biologic and toxic effects on C57BL/6J and DBA/2J inbred mice
- Creators
- Larry W Robertson - Department of Veterinary Physiology and Pharmacology, Texas A&M University, College Station, TX 77843 U.S.AAndrew Parkinson - Department of Chemistry and Biochemistry, University of Guelph, Guelph, Ontario NIG2WI CanadaStelvio Bandiera - Department of Veterinary Physiology and Pharmacology, Texas A&M University, College Station, TX 77843 U.S.AIain Lambert - Department of Veterinary Physiology and Pharmacology, Texas A&M University, College Station, TX 77843 U.S.AJill Merrill - Department of Veterinary Physiology and Pharmacology, Texas A&M University, College Station, TX 77843 U.S.AStephen H Safe - Department of Chemistry and Biochemistry, University of Guelph, Guelph, Ontario NIG2WI Canada
- Resource Type
- Journal article
- Publication Details
- Toxicology (Amsterdam), Vol.31(3), pp.191-206
- Publisher
- Elsevier Ireland Ltd
- DOI
- 10.1016/0300-483X(84)90101-X
- PMID
- 6330936
- ISSN
- 0300-483X
- eISSN
- 1879-3185
- Language
- English
- Date published
- 1984
- Academic Unit
- Occupational and Environmental Health
- Record Identifier
- 9984002595802771
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