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PD-L1 expression in tumor metastasis is different between uveal melanoma and cutaneous melanoma
Journal article   Open access   Peer reviewed

PD-L1 expression in tumor metastasis is different between uveal melanoma and cutaneous melanoma

Asad Javed, David Arguello, Curtis Johnston, Zoran Gatalica, Mizue Terai, Ryan M Weight, Marlana Orloff, Michael J Mastrangelo and Takami Sato
Immunotherapy, Vol.9(16), pp.1323-1330
12/2017
DOI: 10.2217/imt-2017-0066
PMID: 29185395
url
https://doi.org/10.2217/imt-2017-0066View
Published (Version of record) Open Access

Abstract

To compare PD-L1 expression between metastatic uveal melanoma (MUM) and metastatic cutaneous melanoma (MCM). A total of 295 MCM and 78 MUM specimens were analyzed for tumor cell PD-L1 expression. Additionally, 91 MCM and 45 MUM specimens were analyzed for PD-1 expression on tumor-infiltrating lymphocytes.  A total of 77/295 (26.1%) MCM specimens expressed PD-L1 as compared to 4/78 (5.1%) MUM specimens (p < 0.0001). PD-1 expression on tumor-infiltrating lymphocytes was greater in MCM (73.6%; 67/91) than in MUM (51.1%; 23/45), respectively (p = 0.009). Significant differences exist in PD-L1 expression between MCM and MUM. The lower PD-L1 expression in MUM may provide a rationale for failure of PD-1 inhibitor therapy and suggests that immune evasion in this disease may occur via alternative mechanisms.
 Antibodies, Monoclonal - therapeutic use B7-H1 Antigen - immunology Diagnosis, Differential Gene Expression Regulation Humans Immunotherapy - methods Lymphocytes, Tumor-Infiltrating - physiology Melanoma - diagnosis Melanoma - metabolism Melanoma - therapy Neoplasm Metastasis Prognosis Skin Neoplasms - diagnosis Skin Neoplasms - metabolism Skin Neoplasms - therapy Treatment Outcome Tumor Escape Uveal Neoplasms - diagnosis Uveal Neoplasms - metabolism Uveal Neoplasms - therapy

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