Journal article
PDE6D binds to the C‐terminus of RPGR in a prenylation‐dependent manner
EMBO Reports, Vol.16(12), pp.1581-1582
12/2015
DOI: 10.15252/embr.201541220
PMCID: PMC4693524
PMID: 26553938
Abstract
Contrary to the prior studies, PDE 6D was found to bind more preferentially to the C‐terminal prenyl moiety than the N‐terminal region of RPGR in mammalian cells. This RPGR – PDE 6D interaction is also dependent on the amino acid adjacent to the prenylation motif, providing an explanation as to how the specificity of PDE 6D and prenylated protein interaction is determined.
Details
- Title: Subtitle
- PDE6D binds to the C‐terminus of RPGR in a prenylation‐dependent manner
- Creators
- Je‐Jung Lee - University of IowaSeongjin Seo - University of Iowa Carver College of Medicine
- Resource Type
- Journal article
- Publication Details
- EMBO Reports, Vol.16(12), pp.1581-1582
- Publisher
- John Wiley and Sons Inc; Hoboken
- DOI
- 10.15252/embr.201541220
- PMID
- 26553938
- PMCID
- PMC4693524
- ISSN
- 1469-221X
- eISSN
- 1469-3178
- Language
- English
- Date published
- 12/2015
- Academic Unit
- Ophthalmology and Visual Sciences
- Record Identifier
- 9983979956502771
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