Journal article
PEGylation strategies for active targeting of PLA/PLGA nanoparticles
Journal of biomedical materials research. Part A, Vol.91A(1), pp.263-276
10/01/2009
DOI: 10.1002/jbm.a.32247
PMID: 18980197
Abstract
This work evaluates various techniques for the incorporation of poly(ethylene glycol) (PEG) onto biodegradable nanoparticles (NPs) of poly(lactic-co-glycolic acid) (PLGA) or poly(lactic acid) (PLA) with the purpose of providing a functional site for surface conjugation of targeting agents and for improving surface properties. The techniques compared were based on NP preparation with blends of PLGA and poloxamer or with block copolymers of PLGA/PLA with PEG. Blending of PLGA with poloxamer 407 resulted in the incorporation of the latter to up to a 43 wt % content. Direct conjugation of heterofunctional NH2-PEG-COOH to the surface of pre- made NPs was not highly effective. Preparation of copolymers of PLGA with PEG was determined to be more effective and versatile by polymerization of lactide and glycolide dimers onto the hydroxyl group of heterofunctional OH-PEG-COOH than by conjugation of the premade polymers with carbodiimide chemistry. NPs prepared with these copolymers confirmed the surface localization of PEG and proved to be useful for conjugation of mouse immumoglobulin as a model targeting agent. (C) 2008 Wiley Periodicals, Inc. J Biomed Mater Res 91A: 263-276, 2009
Details
- Title: Subtitle
- PEGylation strategies for active targeting of PLA/PLGA nanoparticles
- Creators
- Tania Betancourt - The University of Texas at AustinJames D. Byrne - The University of Texas at AustinNicole Sunaryo - The University of Texas at AustinSpencer W. Crowder - The University of Texas at AustinMeena Kadapakkam - The University of Texas at AustinShefali Patel - The University of Texas at AustinShelly Casciato - The University of Texas at AustinLisa Brannon-Peppas - The University of Texas at Austin
- Resource Type
- Journal article
- Publication Details
- Journal of biomedical materials research. Part A, Vol.91A(1), pp.263-276
- Publisher
- Wiley
- DOI
- 10.1002/jbm.a.32247
- PMID
- 18980197
- ISSN
- 1549-3296
- eISSN
- 1552-4965
- Number of pages
- 14
- Grant note
- The University of Texas Thrust 2000 The University of Texas Undergraduate Research Fellowship David and Mary Miller Fellowships National Science Foundation Integrative Graduate Education and Research Traineeship; National Science Foundation (NSF)
- Language
- English
- Date published
- 10/01/2009
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Radiation Oncology
- Record Identifier
- 9984274755702771
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