Journal article
PET Imaging Reveals Early Pulmonary Perfusion Abnormalities in HIV Infection Similar to Smoking
The Journal of nuclear medicine (1978), Vol.62(3), pp.405-411
03/01/2021
DOI: 10.2967/jnumed.120.245977
PMCID: PMC8049351
PMID: 32764123
Abstract
Chronic obstructive pulmonary disease (COPD) is the most common noninfectious pulmonary disease among people living with HIV, independent of smoking. However, the cause for this enhanced susceptibility remains unclear, and the effects of HIV on pulmonary perfusion and ventilation are unknown. Methods: We used PET/CT in 46 smokers and nonsmokers, 23 of whom had documented HIV infection. Emphysema was assessed by CT and perfusion by N-13 ((NN)-N-13) PET scans. After removal of image noise, vertical and axial gradients in perfusion were calculated. We tested for differences in the total spatial heterogeneity of perfusion (CVQtotal2) and its components (CVQtotal22 = CVQvgrad2 [vertical gradient] + CVQzgrad2 [axial gradient] + CVQr2 [residual heterogeneity]) among groups. Results: There were no significant differences in demographic parameters among groups, and all subjects had minimal radiographic evidence of emphysema. Compared with controls, nonsmokers living with HIV had a significantly greater CVQr2/CVQtotal2 (0.48 vs. 0.36, P = 0.05) and reduced CVQvgrad2/CVQtotal2 (0.46 vs. 0.65, P = 0.038). Smokers also had a reduced CVQvgrad2/CVQtotal2, however, there was no significant difference in CVQvgrad2/CVQtotal2 between smokers living with and without HIV (0.39 vs. 0.34, P = 0.58), despite a decreased vertical perfusion gradient (Qv(grad))in smokers living with HIV. Conclusion: In nonsmokers living with well-controlled HIV and minimal radiographic emphysema, HIV infection contributes to pulmonary perfusion abnormalities similar to smokers. These data indicate the onset of subclinical pulmonary perfusion abnormalities that could herald the development of significant lung disease in these susceptible individuals.
Details
- Title: Subtitle
- PET Imaging Reveals Early Pulmonary Perfusion Abnormalities in HIV Infection Similar to Smoking
- Creators
- Puja Kohli - Massachusetts General HospitalVanessa J. Kelly - Massachusetts General HospitalKathryn A. Hibbert - Massachusetts General HospitalBjorn Corleis - Ragon Institute of MGH, MIT and HarvardMamary Kone - Massachusetts General HospitalJosalyn L. Cho - University of IowaDoreen DeFaria-Yeh - Harvard UniversityDouglas S. Kwon - Harvard UniversityBenjamin D. Medoff - Massachusetts General HospitalR. Scott Harris - Massachusetts General HospitalTilo Winkler - Massachusetts General Hospital
- Resource Type
- Journal article
- Publication Details
- The Journal of nuclear medicine (1978), Vol.62(3), pp.405-411
- Publisher
- Soc Nuclear Medicine Inc
- DOI
- 10.2967/jnumed.120.245977
- PMID
- 32764123
- PMCID
- PMC8049351
- ISSN
- 0161-5505
- eISSN
- 1535-5667
- Number of pages
- 7
- Language
- English
- Date published
- 03/01/2021
- Academic Unit
- Pulmonary, Critical Care, and Occupational Medicine; Internal Medicine
- Record Identifier
- 9984359869502771
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