PET/CT imaging of age- and task-associated differences in muscle activity during fatiguing contractions

Thorsten Rudroff; Kari K Kalliokoski; Derek E Block; Jeffrey R Gould; William C Klingensmith III; Roger M Enoka

doi:10.1152/japplphysiol.01439.2012

Back

PET/CT imaging of age- and task-associated differences in muscle activity during fatiguing contractions

Journal article

Open access

Peer reviewed

PET/CT imaging of age- and task-associated differences in muscle activity during fatiguing contractions

Thorsten Rudroff, Kari K Kalliokoski, Derek E Block, Jeffrey R Gould, William C Klingensmith III and Roger M Enoka

Journal of applied physiology (1985), Vol.114(9), pp.1211-1219

05/2013

DOI: 10.1152/japplphysiol.01439.2012

PMCID: PMC3656430

PMID: 23412899

Files and links (1)

url

https://doi.org/10.1152/japplphysiol.01439.2012View

Published (Version of record) Open Access

Abstract

The study compared positron emission tomography/computed tomography (PET/CT) of [(18)F]-2-fluoro-2-deoxy-D-glucose ([(18)F]-FDG) uptake by skeletal muscles and the amount of muscle activity as indicated by surface electromyographic (EMG) recordings when young and old men performed fatiguing isometric contractions that required either force or position control. EMG signals were recorded from thigh muscles of six young men (26 ± 6 yr) and six old men (77 ± 6 yr) during fatiguing contractions with the knee extensors. PET/CT scans were performed immediately after task failure. Glucose uptake in 24 leg muscles, quantified as standardized uptake values, was greater for the old men after the force task and differed across tasks for the young men (force, 0.64 ± 0.3 g/ml; position, 0.73 ± 0.3 g/ml), but not the old men (force, 0.84 ± 0.3 g/ml; position, 0.79 ± 0.26 g/ml) (age × task interaction; P < 0.001). In contrast, the rate of increase in EMG amplitude for the agonist muscles was greater for the young men during the two contractions and there was no difference for either group of subjects in the rate of increase in EMG amplitude across the two tasks. The imaging estimates of glucose uptake indicated age- and task-dependent differences in the spatial distribution of [(18)F]-FDG uptake by skeletal muscles during fatiguing contractions. The findings demonstrate that PET/CT imaging of [(18)F]-FDG uptake, but not surface EMG recordings, detected the modulation of muscle activity across the fatiguing tasks by the young men but not the old men.

Electromyography

Humans

Male

Muscle, Skeletal - physiology

Physical Endurance - physiology

Leg

Young Adult

Multimodal Imaging

Aging - physiology

Muscle, Skeletal - diagnostic imaging

Radionuclide Imaging

Aged, 80 and over

Adult

Fluorodeoxyglucose F18

Aged

Fluorine Radioisotopes

Muscle Fatigue - physiology

Radiopharmaceuticals

Isometric Contraction - physiology

Details

Title: Subtitle: PET/CT imaging of age- and task-associated differences in muscle activity during fatiguing contractions
Creators: Thorsten Rudroff - Department of Integrative Physiology, University of Colorado, Boulder, Colorado 80523-1582, USA. thorsten.rudroff@colostate.edu
Kari K Kalliokoski
Derek E Block
Jeffrey R Gould
William C Klingensmith III
Roger M Enoka
Resource Type: Journal article
Publication Details: Journal of applied physiology (1985), Vol.114(9), pp.1211-1219
DOI: 10.1152/japplphysiol.01439.2012
PMID: 23412899
PMCID: PMC3656430
NLM abbreviation: J Appl Physiol (1985)
ISSN: 8750-7587
eISSN: 1522-1601
Publisher: United States
Grant note: AG033744 / NIA NIH HHS
Language: English
Date published: 05/2013
Academic Unit: Neurology; Health, Sport, and Human Physiology
Record Identifier: 9984002371402771

Metrics

16 Record Views

31 Times Cited - Web of Science