Journal article
PGC-1 proteins and heart failure
Trends in cardiovascular medicine, Vol.22(4), pp.98-105
05/2012
DOI: 10.1016/j.tcm.2012.07.003
PMCID: PMC3466400
PMID: 22939990
Abstract
The transcriptional coactivators PGC-1α and PGC-1β are master regulators of oxidative phosphorylation and fatty acid oxidation gene expression. Pressure overload hypertrophy and heart failure are associated with repressed PGC-1α and PGC-1β gene expression. Maintaining expression of PGC-1α and -β preserves contractile function in response to a pathological increase in workload. Here, we discuss the regulation of PGC-1 proteins under conditions of pressure overload hypertrophy and heart failure.
Details
- Title: Subtitle
- PGC-1 proteins and heart failure
- Creators
- Christian Riehle - Division of Endocrinology, Metabolism and Diabetes, Program in Molecular Medicine, University of Utah School of Medicine, Salt Lake City, UT 84112, USAE Dale Abel
- Resource Type
- Journal article
- Publication Details
- Trends in cardiovascular medicine, Vol.22(4), pp.98-105
- DOI
- 10.1016/j.tcm.2012.07.003
- PMID
- 22939990
- PMCID
- PMC3466400
- NLM abbreviation
- Trends Cardiovasc Med
- ISSN
- 1050-1738
- eISSN
- 1873-2615
- Publisher
- United States
- Grant note
- R01 HL108379 / NHLBI NIH HHS R01 DK092065 / NIDDK NIH HHS U01 HL087947 / NHLBI NIH HHS
- Language
- English
- Date published
- 05/2012
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Fraternal Order of Eagles Diabetes Research Center; Biochemistry and Molecular Biology; Endocrinology and Metabolism; Internal Medicine
- Record Identifier
- 9984025279102771
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