Journal article
PI3K signaling: A key pathway in the control of sympathetic traffic and arterial pressure by leptin
Molecular metabolism (Germany), Vol.2(2), pp.69-73
04/2013
DOI: 10.1016/j.molmet.2013.03.004
PMCID: PMC3817392
PMID: 24199153
Abstract
The adipocyte-derived hormone, leptin, is a master regulator of energy homeostasis. Leptin action in the central nervous system also contributes to arterial pressure regulation through its capacity to increase renal sympathetic outflow. The accumulating evidence pointing to a key role for leptin in the adverse sympathetic and cardiovascular consequences of excessive adiposity highlight the importance of understanding the mechanisms underlying the sympathetic and cardiovascular effects of leptin. The ability of the leptin receptor to stimulate various intracellular pathways allows leptin to regulate physiological processes in a specific manner. In this review, we examine the role of the PI3K pathway emanating from the leptin receptor in mediating the sympathetic and arterial pressure effects of leptin. We also discuss the relevance of PI3K signaling for obesity-induced hypertension through its role in mediating selective leptin resistance.
Details
- Title: Subtitle
- PI3K signaling: A key pathway in the control of sympathetic traffic and arterial pressure by leptin
- Creators
- Shannon M Harlan - Department of Pharmacology, University of Iowa Carver College of Medicine, Iowa City, IA, USAKamal Rahmouni - Department of Pharmacology, University of Iowa Carver College of Medicine, Iowa City, IA, USA
- Resource Type
- Journal article
- Publication Details
- Molecular metabolism (Germany), Vol.2(2), pp.69-73
- DOI
- 10.1016/j.molmet.2013.03.004
- PMID
- 24199153
- PMCID
- PMC3817392
- NLM abbreviation
- Mol Metab
- ISSN
- 2212-8778
- eISSN
- 2212-8778
- Publisher
- Elsevier GmbH
- Grant note
- DOI: 10.13039/100000002, name: National Institutes of Health, award: HL084207; DOI: 10.13039/100000041, name: American Diabetes Association, award: 1-11-BS-127; name: University of Iowa Fraternal Order of Eagles Diabetes Center; name: Postdoctoral Fellowship Award from The American Heart Association, award: 12POST9410009
- Language
- English
- Date published
- 04/2013
- Academic Unit
- Iowa Neuroscience Institute; Neuroscience and Pharmacology; Internal Medicine
- Record Identifier
- 9984040281102771
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