Journal article
PIEZOs mediate neuronal sensing of blood pressure and the baroreceptor reflex
Science (American Association for the Advancement of Science), Vol.362(6413), pp.464-467
10/26/2018
DOI: 10.1126/science.aau6324
PMCID: PMC6563913
PMID: 30361375
Abstract
Activation of stretch-sensitive baroreceptor neurons exerts acute control over heart rate and blood pressure. Although this homeostatic baroreflex has been described for more than 80 years, the molecular identity of baroreceptor mechanosensitivity remains unknown. We discovered that mechanically activated ion channels PIEZO1 and PIEZO2 are together required for baroreception. Genetic ablation of both
and
in the nodose and petrosal sensory ganglia of mice abolished drug-induced baroreflex and aortic depressor nerve activity. Awake, behaving animals that lack
had labile hypertension and increased blood pressure variability, consistent with phenotypes in baroreceptor-denervated animals and humans with baroreflex failure. Optogenetic activation of
-positive sensory afferents was sufficient to initiate baroreflex in mice. These findings suggest that PIEZO1 and PIEZO2 are the long-sought baroreceptor mechanosensors critical for acute blood pressure control.
Details
- Title: Subtitle
- PIEZOs mediate neuronal sensing of blood pressure and the baroreceptor reflex
- Creators
- Wei-Zheng Zeng - Scripps Research InstituteKara L Marshall - Scripps Research InstituteSoohong Min - Howard Hughes Medical Institute, Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USAIhab Daou - Scripps Research InstituteMark W Chapleau - Roy J. and Lucille A. Carver College of MedicineFrancois M Abboud - Roy J. and Lucille A. Carver College of MedicineStephen D Liberles - Howard Hughes Medical InstituteArdem Patapoutian - Scripps Research Institute
- Resource Type
- Journal article
- Publication Details
- Science (American Association for the Advancement of Science), Vol.362(6413), pp.464-467
- DOI
- 10.1126/science.aau6324
- PMID
- 30361375
- PMCID
- PMC6563913
- ISSN
- 0036-8075
- eISSN
- 1095-9203
- Grant note
- P01 HL014388 / NHLBI NIH HHS OT2 OD023848 / NIH HHS DP1 AT009497 / NCCIH NIH HHS R35 NS105067 / NINDS NIH HHS Howard Hughes Medical Institute R01 DE022358 / NIDCR NIH HHS
- Language
- English
- Date published
- 10/26/2018
- Academic Unit
- Molecular Physiology and Biophysics; Cardiovascular Medicine; Fraternal Order of Eagles Diabetes Research Center; Internal Medicine
- Record Identifier
- 9984297601202771
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