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PLASMA GLUCAGON AND ALANINE RESPONSES TO ACUTE INSULIN DEFICIENCY IN MAN
Journal article   Peer reviewed

PLASMA GLUCAGON AND ALANINE RESPONSES TO ACUTE INSULIN DEFICIENCY IN MAN

John E Gerich, Eva Tsalikian, Mara Lorenzi, John H Karam and Dennis M Bier
The journal of clinical endocrinology and metabolism, Vol.40(3), pp.526-529
03/1975
DOI: 10.1210/jcem-40-3-526
PMID: 1117061

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Abstract

Plasma glucagon levels rose within 1 hr after withdrawal of insulin in 7 juvenile-type diabetics previously kept normoglycemic by prolonged intravenous infusions of insulin. These changes preceded subsequent elevations in plasma alanine levels. Individual rises in plasma glucagon were correlated with elevations in plasma glucose, beta-hydroxybutyrate, free fatty acid, and glycerol levels, suggesting that glucagon may play an important role in the development of diabetic ketoacidosis in man.

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