Journal article
POTASSIUM CHANNELS AND THE CEREBRAL CIRCULATION
Clinical and experimental pharmacology & physiology, Vol.23(12), pp.1091-1095
12/1996
DOI: 10.1111/j.1440-1681.1996.tb01175.x
PMID: 8977165
Abstract
SUMMARY
1. Hyperpolarization of vascular muscle in response to activation of potassium channels is a major mechanism of vasodilatation.
2. In cerebral blood vessels, two potassium channels have received considerable study recently: ATP‐sensitive and calcium‐dependent potassium channels. Activation of these potassium channels appears to play a major role in the relaxation of cerebral arteries and arterioles in response to diverse stimuli, including receptor‐mediated agonists, intracellular second messengers, reactive oxygen species and hypoxia.
3. The functional influence of ATP‐sensitive and calcium‐dependent potassium channels may be altered in disease states, including hypertension, diabetes and subarachnoid haemorrhage.
Details
- Title: Subtitle
- POTASSIUM CHANNELS AND THE CEREBRAL CIRCULATION
- Creators
- Frank M FaraciChristopher G Sobey
- Resource Type
- Journal article
- Publication Details
- Clinical and experimental pharmacology & physiology, Vol.23(12), pp.1091-1095
- Publisher
- Blackwell Publishing Ltd; Oxford, UK
- DOI
- 10.1111/j.1440-1681.1996.tb01175.x
- PMID
- 8977165
- ISSN
- 0305-1870
- eISSN
- 1440-1681
- Number of pages
- 5
- Language
- English
- Date published
- 12/1996
- Academic Unit
- Cardiovascular Medicine; Neuroscience and Pharmacology; Internal Medicine
- Record Identifier
- 9984040592402771
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