Journal article
POTENTIAL RISK OF BRAIN DAMAGE AND POOR DEVELOPMENTAL OUTCOMES IN CHILDREN PRENATALLY EXPOSED TO SARS-COV-2: A SYSTEMATIC REVIEW
Revista paulista de pediatria, Vol.40, pp.e2020415-e2020415
01/01/2022
DOI: 10.1590/1984-0462/2022/40/2020415
PMCID: PMC8240623
PMID: 34076204
Abstract
Objective: To perform a systematic literature review to analyze existing data on the neurological effects of coronavirus on newborns.
Data sources: We followed the guidelines of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) and the Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols (PRISMA-P), and searched the PubMed and Embase platforms for the keywords [brain damage OR pregnancy OR developmental outcomes] and [coronavirus OR SARS-CoV-2 OR SARS-CoV OR MERS-CoV] between January 1, 2000 and June 1, 2020.
Data synthesis: Twenty-three reports described the course of pregnant women exposed to SARS-CoV-2, SARS-CoV, or MERSCoV during the gestational period, eight to SARS-CoV-2, eight to SARS-CoV, and seven to MERS-CoV. No data were found on abnormalities in brain development or on a direct link between the virus and neurological abnormalities in the human embryo, fetus, or children. Spontaneous miscarriage, stillbirth, and termination of pregnancy were some complications connected with SARS/ MERS-CoV infection. SARS-CoV-2 is not currently associated with complications in the gestational period.
Conclusions: The literature has no data associating exposure to coronavirus during pregnancy with brain malformations and neurodevelopmental disorders. However, despite the lack of reports, monitoring the development of children exposed to SARS-CoV-2 is essential given the risk of complications in pregnant women and the potential neuroinvasive and neurotropic properties found in previous strains.
Details
- Title: Subtitle
- POTENTIAL RISK OF BRAIN DAMAGE AND POOR DEVELOPMENTAL OUTCOMES IN CHILDREN PRENATALLY EXPOSED TO SARS-COV-2: A SYSTEMATIC REVIEW
- Creators
- Marcio Leyser - University of IowaFernanda Jordao Pinto Marques - Universidade Federal FluminenseOsvaldo Jose Moreira do Nascimento - Universidade Federal Fluminense
- Resource Type
- Journal article
- Publication Details
- Revista paulista de pediatria, Vol.40, pp.e2020415-e2020415
- DOI
- 10.1590/1984-0462/2022/40/2020415
- PMID
- 34076204
- PMCID
- PMC8240623
- NLM abbreviation
- Rev Paul Pediatr
- ISSN
- 0103-0582
- eISSN
- 2359-3482
- Publisher
- SOC PEDIATRIA SAO PAULO
- Number of pages
- 9
- Language
- English
- Date published
- 01/01/2022
- Academic Unit
- Stead Family Department of Pediatrics; Developmental and Behavioral Pediatrics
- Record Identifier
- 9984353840102771
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