Journal article
PP2Cγ: a human protein phosphatase with a unique acidic domain
FEBS letters, Vol.412(3), pp.415-419
1997
DOI: 10.1016/S0014-5793(97)00837-5
PMID: 9276438
Abstract
We have cloned a novel cDNA from human skeletal muscle which encodes a protein phosphatase with a unique acidic domain. It is 34% identical to mammalian PP2Cα and PP2Cβ, and we call it PP2Cγ. It more closely resembles PP2Cs from
Paramecium tetraurelia and
Schizosaccharomyces pombe than mammalian PP2Cs. Northern blot analysis shows that PP2Cγ is widely expressed, and is most abundant in testis, skeletal muscle, and heart. Like known PP2Cs, recombinant PP2Cγ requires Mg
2+ or Mn
2+ for activity. Unlike any other known phosphatase, PP2Cγ has a highly acidic domain: 75% of the 54 residues are glutamate or aspartate.
Details
- Title: Subtitle
- PP2Cγ: a human protein phosphatase with a unique acidic domain
- Creators
- Sue M Travis - Department of Internal Medicine, 500 EMRB, University of Iowa College of Medicine, Iowa City, IA 52242, USAMichael J Welsh - Department of Internal Medicine, 500 EMRB, University of Iowa College of Medicine, Iowa City, IA 52242, USA
- Resource Type
- Journal article
- Publication Details
- FEBS letters, Vol.412(3), pp.415-419
- DOI
- 10.1016/S0014-5793(97)00837-5
- PMID
- 9276438
- NLM abbreviation
- FEBS Lett
- ISSN
- 0014-5793
- eISSN
- 1873-3468
- Publisher
- Elsevier B.V
- Language
- English
- Date published
- 1997
- Academic Unit
- Neurology; Molecular Physiology and Biophysics; Pulmonary, Critical Care, and Occupational Medicine; Neurosurgery; Internal Medicine
- Record Identifier
- 9984020855402771
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