Journal article
PROGNOSIS OF DIFFERENTIATED THYROID CARCINOMA IN PATIENTS WITH GRAVES DISEASE: A SYSTEMATIC REVIEW AND META-ANALYSIS
Endocrine practice, Vol.25(12), pp.1323-1337
12/01/2019
DOI: 10.4158/EP-2019-0201
PMID: 31412224
Abstract
Objective: It is still controversial whether differentiated thyroid carcinoma (DTC) in patients with Graves disease (GD) can be more aggressive than non-Graves DTC. We conducted a systematic review and meta-analysis to examine the association between GD and prognosis in patients with DTC.
Methods: We comprehensively searched the databases of MEDLINE and EMBASE from inception to March 2019. We included published studies that compared the risk of mortality and prognosis between DTC patients with GD and those with non-GD. Data from each study were combined using the random-effects model.
Results: Twenty-five studies from February 1988 to May 2018 were included (987 DTC patients with GD and 2,064 non-Graves DTC patients). The DTC patients with GD had a significantly higher risk of associated multifocality/multicentricity (odds ratio, 1.45; 95% confidence interval, 1.04 to 2.02; I-2, 6.5%; P = .381) and distant metastasis at the time of cancer diagnosis (odds ratio, 2.19; 95% confidence interval, 1.08 to 4.47; I-2, 0.0%; P = .497), but this was not associated with DTC-related mortality and recurrence/persistence during follow-up.
Conclusion: Our meta-analysis demonstrates a statistically significant increased risk of multifocality/multicentricity and distant metastasis at the time of cancer diagnosis in DTC patients with GD than those without GD.
Details
- Title: Subtitle
- PROGNOSIS OF DIFFERENTIATED THYROID CARCINOMA IN PATIENTS WITH GRAVES DISEASE: A SYSTEMATIC REVIEW AND META-ANALYSIS
- Creators
- Poemlarp Mekraksakit - Texas Tech Univ, Hlth Sci Ctr, Dept Internal Med, Lubbock, TX 79430 USAPattara Rattanawong - University of Hawaii SystemRudruidee Karnchanasorn - University of KansasChanavuth Kanitsoraphan - University of Hawaii SystemNatnicha Leelaviwat - Mahidol UniversityKittika Poonsombudlert - University of Hawaii SystemJakrin Kewcharoen - University of Hawaii SystemSiroj Dejhansathit - Texas Tech Univ, Hlth Sci Ctr, Dept Internal Med, Lubbock, TX 79430 USARaynald Samoa - City Of Hope National Medical Center
- Resource Type
- Journal article
- Publication Details
- Endocrine practice, Vol.25(12), pp.1323-1337
- Publisher
- Amer Assoc Clinical Endocrinologists
- DOI
- 10.4158/EP-2019-0201
- PMID
- 31412224
- ISSN
- 1530-891X
- eISSN
- 1934-2403
- Number of pages
- 15
- Language
- English
- Date published
- 12/01/2019
- Academic Unit
- Internal Medicine
- Record Identifier
- 9984691514302771
Metrics
9 Record Views