Journal article
PROGNOSTIC FACTORS FOR LONG-TERM RENAL FUNCTION IN BOYS WITH THE PRUNE-BELLY SYNDROME
The Journal of urology, Vol.162(4), pp.1399-1401
10/1999
DOI: 10.1016/S0022-5347(05)68320-6
PMID: 10492223
Abstract
Purpose: Renal failure develops in 25 to 30% of patients with the prune- belly syndrome. The clinical parameters associated with renal failure in this condition are not well understood. We determined which factors predict renal failure in children with the prune-belly syndrome. Materials and Methods: We reviewed the records of 35 patients with the prune-belly syndrome who were treated at our hospital during a 37-year period. Nadir serum creatinine, time to nadir creatinine, presence or absence of a patent urachus, presence and severity of urinary tract infection, and renal failure were analyzed. Results: Mean followup was 14 years 2 months. In 2 of the 17 patients with a nadir serum creatinine of less than 0.7 mg./dl. renal failure developed. Each of these 2 children also had clinical pyelonephritis and urosepsis. In 12 of the 13 patients nadir serum creatinine greater than 0.7 mg./dl. strongly predicted renal failure. Nonfebrile urinary tract infection within the first year of life was not predictive of outcome (p = 0.8) but a history of clinical pyelonephritis correlated with eventual renal failure (p <0.001). Urosepsis also correlated with renal failure (p = 0.008). Children with at least 1 normal kidney on renal ultrasound or renal scan had a significantly lower chance of renal failure (p <0.001). Conclusions: Bilaterally abnormal kidneys on ultrasound or renal scan, a nadir serum creatinine of greater than 0.7 mg./dl. and clinical pyelonephritis are prognostic for renal failure.
Details
- Title: Subtitle
- PROGNOSTIC FACTORS FOR LONG-TERM RENAL FUNCTION IN BOYS WITH THE PRUNE-BELLY SYNDROME
- Creators
- PAUL H. Noh - Children's Hospital of PhiladelphiaCHRISTOPHER S. Cooper - Children's Hospital of PhiladelphiaALFRED C. Winkler - Children's Hospital of PhiladelphiaSTEPHEN A. Zderic - Children's Hospital of PhiladelphiaHOWARD M. Snyder - Children's Hospital of PhiladelphiaDOUGLAS A. Canning - Children's Hospital of Philadelphia
- Resource Type
- Journal article
- Publication Details
- The Journal of urology, Vol.162(4), pp.1399-1401
- DOI
- 10.1016/S0022-5347(05)68320-6
- PMID
- 10492223
- ISSN
- 0022-5347
- eISSN
- 1527-3792
- Language
- English
- Date published
- 10/1999
- Academic Unit
- Stead Family Department of Pediatrics; Urology; Medicine Administration
- Record Identifier
- 9984320070402771
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