PROGRAD – An observational study of the prognosis of inpatients evaluated for palliative radiotherapy

Andre Tsin Chih Chen; Geovanne Pedro Mauro; Flavia Gabrielli; Cristiane de Lacerda Gonçalves Chaves; Igor Castro; Karina Moutinho Vasconcelos; Milena Reis; Thalita Saraiva; Heloisa Andrade de Carvalho

doi:10.1016/j.radonc.2018.03.021

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PROGRAD – An observational study of the prognosis of inpatients evaluated for palliative radiotherapy

Journal article

Peer reviewed

PROGRAD – An observational study of the prognosis of inpatients evaluated for palliative radiotherapy

Andre Tsin Chih Chen, Geovanne Pedro Mauro, Flavia Gabrielli, Cristiane de Lacerda Gonçalves Chaves, Igor Castro, Karina Moutinho Vasconcelos, Milena Reis, Thalita Saraiva and Heloisa Andrade de Carvalho

Radiotherapy and oncology, Vol.127(2), pp.299-303

05/01/2018

DOI: 10.1016/j.radonc.2018.03.021

PMID: 29625809

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http://dx.doi.org/10.1016/j.radonc.2018.03.021View

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Abstract

Low-and-middle-income countries have resource constraints and waiting lists for radiotherapy (RT). In this context, we sought to determine the survival of inpatients evaluated for palliative RT in a large referral cancer center in Brazil. From November 2014 through December 2015, we enrolled 333 inpatients with palliative RT evaluation requests in this prospective observational study. We applied Palliative Prognostic Index (PPI) and Survival Prediction Score using Number of Risk Factors (NRF). Primary endpoint was overall survival. Secondary endpoints were survival by PPI and NRF. (ClinicalTrials.gov number, NCT02312791). Median survival (MS) for the entire cohort was 73 days. PPI ≤2 had MS of 120 days; PPI 2.5–4 had MS of 55 days (HR 1.84; 95% CI, 1.07–3.16); PPI >4 had MS of 39 days (HR 3.45; 95% CI, 2.07–5.74) (p < .0001). NRF 0–1 had MS of 129 days; NRF 2 had MS of 73 days (HR 1.74; 95% CI 0.89–3.38); NRF 3 had MS of 40 days (HR 2.95; 95% CI, 1.50–5.78) (p < .0001). Inpatients with palliative RT requests seem to have an overall poor survival. PPI and NRF can define subgroups with different prognosis. This could help hospitals and healthcare systems to standardize criteria for prioritization and contribute for fairness.

Healthcare delivery

Palliation

Prognosis

Radiotherapy

Details

Title: Subtitle: PROGRAD – An observational study of the prognosis of inpatients evaluated for palliative radiotherapy
Creators: Andre Tsin Chih Chen - Instituto do Câncer do Estado de São Paulo
Geovanne Pedro Mauro - Instituto do Câncer do Estado de São Paulo
Flavia Gabrielli - Instituto do Câncer do Estado de São Paulo
Cristiane de Lacerda Gonçalves Chaves - Instituto do Câncer do Estado de São Paulo
Igor Castro - Instituto do Câncer do Estado de São Paulo
Karina Moutinho Vasconcelos - Instituto do Câncer do Estado de São Paulo
Milena Reis - Instituto do Câncer do Estado de São Paulo
Thalita Saraiva - Instituto do Câncer do Estado de São Paulo
Heloisa Andrade de Carvalho - Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo
Resource Type: Journal article
Publication Details: Radiotherapy and oncology, Vol.127(2), pp.299-303
DOI: 10.1016/j.radonc.2018.03.021
PMID: 29625809
NLM abbreviation: Radiother Oncol
ISSN: 0167-8140
eISSN: 1879-0887
Publisher: Elsevier B.V
Number of pages: 5
Language: English
Date published: 05/01/2018
Academic Unit: Radiation Oncology
Record Identifier: 9984914148902771

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