Journal article
PROPOSED METABOLIC VICIOUS CIRCLE IN PATIENTS WITH LARGE MYOCARDIAL INFARCTS AND HIGH PLASMA-FREE-FATTY-ACID CONCENTRATIONS
The Lancet (British edition), Vol.310(8044), pp.890-892
1977
DOI: 10.1016/S0140-6736(77)90830-3
Abstract
The relation between peak plasma-free-fatty-acid (F.F.A.) concentration and size of infarct—as estimated by the plasma-creatine-kinase technique—was investigated in twenty patients with acute myocardial infarction. In eight patients with large infarcts (more than 65 g equivalents) mean infarct size was 136±21 g equivalents and mean peak F.F.A. value in the first 12 h was 1·99±0·14 mmol/l (mean ±S.E.M.). In twelve patients with small infarcts, mean infarct size was 36±5 g equivalents and mean peak P.P.A. was 1·22+0·13 mmol/l (p<0·001). Experimental evidence suggests that high circulating F.F.A. concentrations could further extend ischæemic damage. The association between high plasma-F.F.A. and infarct size may give rise to a vicious circle which increases the severity of the ischæmic process in patients with high plasma-F.F.A.
Details
- Title: Subtitle
- PROPOSED METABOLIC VICIOUS CIRCLE IN PATIENTS WITH LARGE MYOCARDIAL INFARCTS AND HIGH PLASMA-FREE-FATTY-ACID CONCENTRATIONS
- Creators
- LionelH Opie - University of Cape TownMichael Tansey - University of Cape TownBrianM Kennelly - University of Cape Town
- Resource Type
- Journal article
- Publication Details
- The Lancet (British edition), Vol.310(8044), pp.890-892
- Publisher
- Elsevier Ltd
- DOI
- 10.1016/S0140-6736(77)90830-3
- ISSN
- 0140-6736
- eISSN
- 1474-547X
- Language
- English
- Date published
- 1977
- Academic Unit
- Stead Family Department of Pediatrics; Fraternal Order of Eagles Diabetes Research Center; Endocrinology and Diabetes
- Record Identifier
- 9984353925902771
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