PXR: a xenobiotic receptor of diverse function implicated in pharmacogenetics

Bin Zhang; Wen Xie; Matthew D Krasowski

doi:10.2217/14622416.9.11.1695

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PXR: a xenobiotic receptor of diverse function implicated in pharmacogenetics

Journal article

Open access

Peer reviewed

PXR: a xenobiotic receptor of diverse function implicated in pharmacogenetics

Bin Zhang, Wen Xie and Matthew D Krasowski

Pharmacogenomics, Vol.9(11), pp.1695-1709

11/2008

DOI: 10.2217/14622416.9.11.1695

PMCID: PMC2593625

PMID: 19018724

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http://doi.org/10.2217/14622416.9.11.1695View

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Abstract

The pregnane X receptor (PXR; NR1I2), a member of the nuclear receptor superfamily, regulates the expression of drug-metabolic enzymes and transporters involved in the responses of mammals to their chemical environment. The same enzyme and transporter systems are also involved in the homeostasis of numerous endogenous chemicals. The regulatory function of PXR is implicated in normal physiology and diseases, such as drug-drug interactions, hepatic steatosis, vitamin D homeostasis, bile acids homeostasis, steroid hormones homeostasis and inflammatory bowel diseases. As such, any genetic variations of this receptor could potentially have widespread effects on the disposition of xenobiotics and endobiotics. Knowledge concerning the genetic polymorphisms of PXR may help to understand the variations in human drug response and ensure safe drug use. The correlation of PXR genetic polymorphisms with several disease conditions also suggests that this receptor may represent a valid therapeutic for hepato-intestinal disorders such as inflammatory bowel disease and primary sclerosing cholangitis.

Pharmacogenetics

Inactivation, Metabolic

Animals

Drug Interactions

Humans

Xenobiotics - pharmacokinetics

Retinoid X Receptors - genetics

Polymorphism, Genetic

Details

Title: Subtitle: PXR: a xenobiotic receptor of diverse function implicated in pharmacogenetics
Creators: Bin Zhang - University of Pittsburgh
Wen Xie
Matthew D Krasowski
Resource Type: Journal article
Publication Details: Pharmacogenomics, Vol.9(11), pp.1695-1709
DOI: 10.2217/14622416.9.11.1695
PMID: 19018724
PMCID: PMC2593625
NLM abbreviation: Pharmacogenomics
ISSN: 1462-2416
eISSN: 1744-8042
Publisher: England
Grant note: R01 ES014626 / NIEHS NIH HHS R01 CA107011-01 / NCI NIH HHS R01 ES012479-01 / NIEHS NIH HHS R01 ES012479 / NIEHS NIH HHS R01 CA107011 / NCI NIH HHS CA107011 / NCI NIH HHS R01 ES014626-01A1 / NIEHS NIH HHS ES012479 / NIEHS NIH HHS K08 GM074238 / NIGMS NIH HHS ES014626 / NIEHS NIH HHS K08-GM074238 / NIGMS NIH HHS
Language: English
Date published: 11/2008
Academic Unit: Pathology
Record Identifier: 9984047691602771

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