Journal article
Paclitaxel-eluting stents reduce neointimal hyperplasia compared to bare metal stents in saphenous vein grafts: intravascular ultrasonography analysis of the SOS (Stenting of Saphenous Vein Grafts) trial
EuroIntervention, Vol.7(8), pp.948-954
12/01/2011
DOI: 10.4244/EIJV7I8A150
PMID: 22157480
Abstract
Aims: To compare the intravascular ultrasonography (IVUS) findings between saphenous vein grafts (SVG) treated with paclitaxel-eluting stents (PES) vs. bare metal stents (BMS) in the Stenting Of Saphenous Vein Grafts (SOS) trial.
Methods and results: Of the 80 SOS trial patients, 38 had both baseline and follow-up IVUS examination and were included in this substudy: 17 patients received 28 BMS in 26 lesions and 21 patients received 30 PES in 28 lesions. Quantitative IVUS analysis was performed to determine the volume of in-stent neointimal hyperplasia (NIH) - defined as the difference between stent volume and lumen volume in the stented segments. Baseline characteristics were similar between patients who did and did not undergo baseline and follow-up IVUS. Patients receiving BMS and PES had similar stent and lumen volumes immediately after stenting. At 12-month follow-up, compared to BMS, PES-treated lesions had significantly less NIH volume (3.4 vs. 21.9 mm(3), p<0.001) and neointima hyperplasia progression (1.6 vs. 17.1 mm(3), p<0.001). No significant differences were seen in the 5 mm segment proximal and distal to the stent.
Conclusions: Compared to BMS, use of PES in SVG lesions is associated with significantly lower NIH formation, which may help explain the improved clinical outcomes with PES in these lesions.
Details
- Title: Subtitle
- Paclitaxel-eluting stents reduce neointimal hyperplasia compared to bare metal stents in saphenous vein grafts: intravascular ultrasonography analysis of the SOS (Stenting of Saphenous Vein Grafts) trial
- Creators
- Omar M. Jeroudi - The University of Texas Southwestern Medical CenterAbdul-Rahman R. Abdel-Karim - The University of Texas Southwestern Medical CenterTesfaldet T. Michael - The University of Texas Southwestern Medical CenterChristopher Lichtenwalter - The University of Texas Southwestern Medical CenterJames A. de Lemos - Internal MedicineOwen Obel - Internal MedicineTayo Addo - Internal MedicineMichele Roesle - Veterans Affairs North Texas Health Care SystemDonald Haagen - Veterans Affairs North Texas Health Care SystemBavana V. Rangan - Veterans Affairs North Texas Health Care SystemDeepa Raghunathan - The University of Texas Southwestern Medical CenterMonica DaSilva - The University of Texas Southwestern Medical CenterBilal Saeed - University of ToledoJoseph K. Bissett - Cent Arkansas Vet Healthcare Syst, Little Rock, AR USARajesh Sachdeva - University of Arkansas for Medical SciencesVassilios V. Voudris - Onassis Cardiac Surgery CenterPanagiotis Karyofillis - Onassis Cardiac Surgery CenterBiswajit Kar - VA Medical CenterJames Rossen - VA Medical CenterPanayotis Fasseas - Medical College of WisconsinPeter Berger - Geisinger Medical CenterSubhash Banerjee - Internal MedicineEmmanouil S. Brilakis - Internal Medicine
- Resource Type
- Journal article
- Publication Details
- EuroIntervention, Vol.7(8), pp.948-954
- Publisher
- Europa Edition
- DOI
- 10.4244/EIJV7I8A150
- PMID
- 22157480
- ISSN
- 1774-024X
- eISSN
- 1969-6213
- Number of pages
- 7
- Grant note
- Boston Scientific VISN-17 / Department of Veterans Affairs; US Department of Veterans Affairs Harris Methodist Foundation Infraredx Johnson and Johnson; Johnson & Johnson; Johnson & Johnson USA Abbott Vascular; Abbott Laboratories T35-HL086346 / NIHLBI; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI)
- Language
- English
- Date published
- 12/01/2011
- Academic Unit
- Neurology; Cardiovascular Medicine; Neurosurgery; Internal Medicine
- Record Identifier
- 9984302208902771
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