Journal article
Pain Susceptibility Phenotypes in Those Free of Knee Pain With or at Risk of Knee Osteoarthritis: The Multicenter Osteoarthritis Study
Arthritis & rheumatology (Hoboken, N.J.), Vol.71(4), pp.542-549
04/2019
DOI: 10.1002/art.40752
PMCID: PMC6442725
PMID: 30307131
Abstract
It is not clear why some individuals develop pain with knee osteoarthritis (OA). We undertook this study to identify pain susceptibility phenotypes (PSPs) and their relationship to incident persistent knee pain (PKP) 2 years later.
We identified individuals free of PKP from the Multicenter Osteoarthritis Study, a longitudinal cohort of older adults with or at risk of knee OA. Latent class analysis was used to determine PSPs that may contribute to development of PKP apart from structural pathology. These included widespread pain, poor sleep, and psychological factors as well as pressure pain threshold and temporal summation (TS) as determined by quantitative sensory testing (QST). We used logistic regression to evaluate the association of sociodemographic factors with PSPs and the relationship of PSPs to the development of PKP over 2 years.
A total of 852 participants were included (mean age 67 years, body mass index 29.5 kg/m
, 55% women). Four PSPs were identified, primarily characterized by varying proportions (low/absent, moderate, or high) of the presence of pressure pain sensitivity and of facilitated TS, reflecting different measures of sensitization. Subjects in the PSP with a high proportion of pressure pain sensitivity and a moderate proportion of facilitated TS were twice as likely to develop incident PKP over 2 years (odds ratio 1.98 [95% confidence interval 1.07-3.68]) compared with subjects in the PSP having a low proportion of sensitization by both measures.
Four PSPs were identified, 3 of which were predominated by QST evidence of sensitization and 1 of which was associated with developing PKP 2 years later. Prevention or amelioration of sensitization may be a novel approach to preventing onset of PKP in OA.
Details
- Title: Subtitle
- Pain Susceptibility Phenotypes in Those Free of Knee Pain With or at Risk of Knee Osteoarthritis: The Multicenter Osteoarthritis Study
- Creators
- Lisa C Carlesso - Université de Montréal, Hôpital Maisonneuve Rosemont Research Institute, Montreal, Quebec, CanadaNeil A Segal - University of Kansas Medical Center, Kansas CityLaura Frey-Law - University of Iowa, Iowa CityYuqing Zhang - Boston University School of Medicine, Boston, MassachusettsLu Na - Boston University School of Medicine, Boston, MassachusettsMichael Nevitt - University of California at San FranciscoCore E Lewis - University of Alabama at BirminghamTuhina Neogi - Boston University School of Medicine, Boston, Massachusetts
- Resource Type
- Journal article
- Publication Details
- Arthritis & rheumatology (Hoboken, N.J.), Vol.71(4), pp.542-549
- DOI
- 10.1002/art.40752
- PMID
- 30307131
- PMCID
- PMC6442725
- NLM abbreviation
- Arthritis Rheumatol
- ISSN
- 2326-5191
- eISSN
- 2326-5205
- Publisher
- United States
- Grant note
- U01 AG018947 / NIA NIH HHS U01 AG018832 / NIA NIH HHS K23 AR055127 / NIAMS NIH HHS K24 AR070892 / NIAMS NIH HHS U01 AG019069 / NIA NIH HHS P60 AR047785 / NIAMS NIH HHS U01-AG-19079 / NIH HHS Canadian Institutes for Health Research R01 AR062506 / NIAMS NIH HHS U01 AG018820 / NIA NIH HHS
- Language
- English
- Date published
- 04/2019
- Academic Unit
- Epidemiology; Nursing; Physical Therapy and Rehabilitation Science
- Record Identifier
- 9984047639402771
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