Journal article
Pair housing does not alter incubation of craving, extinction, and reinstatement after heroin self-administration in female and male rats
Behavioral neuroscience, Vol.137(2), pp.111-119
2023
DOI: 10.1037/bne0000544
PMCID: PMC10033383
PMID: 36521141
Abstract
Evidence suggests that single housing in rats acts as a chronic stressor, raising the possibilities that it contributes to measures of heroin craving and that pair housing ameliorates such measures. This study aimed to determine whether pair housing after heroin self-administration reduces the incubation of craving, extinction, and reinstatement of heroin seeking. Single-housed female and male Sprague-Dawley rats underwent daily 6-hr heroin self-administration, wherein active lever presses produced a heroin infusion paired with light/tone cues. One day after self-administration, rats underwent a baseline cued-seeking test wherein active lever presses only produced light/tone cues. Immediately following this cued-seeking test, rats were either pair-housed with weight- and sex-matched naïve rat or remained single-housed for the rest of the study. For 14 days, rats remained in their homecages, after which they underwent a cued-seeking test to assess the incubation of craving compared to their baseline test. Rats then underwent extinction sessions followed by cue-induced and heroin-primed reinstatements. The findings reveal that pair-housed rats did not differ from single-housed rats in terms of the incubation of craving, extinction, or reinstatement of heroin seeking. Additionally, the results did not reveal any evidence of sex-based differences in the study. The present work indicates that pair housing during the forced abstinence period does not alter measures of heroin craving/seeking. These findings suggest that the chronic stress of single housing specifically during forced abstinence does not contribute to the degree of such measures. (PsycInfo Database Record (c) 2022 APA, all rights reserved).
Details
- Title: Subtitle
- Pair housing does not alter incubation of craving, extinction, and reinstatement after heroin self-administration in female and male rats
- Creators
- Kelle E Nett - Interdisciplinary Neuroscience ProgramRyan T LaLumiere - Department of Psychological and Brain Sciences
- Resource Type
- Journal article
- Publication Details
- Behavioral neuroscience, Vol.137(2), pp.111-119
- DOI
- 10.1037/bne0000544
- PMID
- 36521141
- PMCID
- PMC10033383
- NLM abbreviation
- Behav Neurosci
- ISSN
- 0735-7044
- eISSN
- 1939-0084
- Grant note
- name: Sponsor name not included, award: DA048055
- Language
- English
- Electronic publication date
- 12/15/2022
- Date published
- 2023
- Academic Unit
- Psychological and Brain Sciences; Iowa Neuroscience Institute
- Record Identifier
- 9984339457902771
Metrics
10 Record Views