Journal article
Pairing-specific long-term depression prevented by blockade of PKC or intracellular Ca2
Neuroreport, Vol.9(10), pp.2237-2241
07/13/1998
DOI: 10.1097/00001756-199807130-00016
PMID: 9694206
Abstract
LONG-TERM depression was established in cerebellar Purkinje cells using 20 pairings of a brief, high frequency train of parallel fiber stimulation with a subsequent 100 ms depolrizing current injection. Effects were assessed on the peak amplitude of Purkinje cell excitatory post synaptic potentials (EPSPs) elicited by single parallel fiber test pulses. Intradendritically recorded Purkinje cell EPSPs exhibited long-term (> 20 min) reduction in peak amplitude following paired stimulation but not if pretreated with the protein kinase C inhibitor calphostin C or iontophoretically injected with the calcium chelator EGTA. The similarity of the stimulation protocol and behavioral conditioning paradigms suggests pairing-specific long-term synaptic depression is a valuable model for understanding the cellular mechanisms underlying cerebellar cortical contributions to learning.
Details
- Title: Subtitle
- Pairing-specific long-term depression prevented by blockade of PKC or intracellular Ca2
- Creators
- John Freeman - Behavioral Neuroscience Unit, Laboratory of Adaptive Systems, Building 36 Room B205, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda MD 20892, USA (Shi) (Schreurs) 1Department of Psychology, The University of lowa, lowa City, IA 52242, USATing ShiBernard Schreurs
- Resource Type
- Journal article
- Publication Details
- Neuroreport, Vol.9(10), pp.2237-2241
- Publisher
- Lippincott-Raven Publishers
- DOI
- 10.1097/00001756-199807130-00016
- PMID
- 9694206
- ISSN
- 0959-4965
- eISSN
- 1473-558X
- Language
- English
- Date published
- 07/13/1998
- Academic Unit
- Psychological and Brain Sciences; Iowa Neuroscience Institute
- Record Identifier
- 9984065858902771
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