Pairwise linkage analysis of 11 loci on human chromosome 4

Jeffrey C Murray; Kenneth H  Buetow; Moyra Smith; Leon Carlock; Aravinda Chakravarti; Robert F Ferrell; Lashitew Gedamu; Conrad Gilliam; Rita Shiang; Catherine R DeHaven

Pairwise linkage analysis of 11 loci on human chromosome 4

Journal article

Peer reviewed

Pairwise linkage analysis of 11 loci on human chromosome 4

Jeffrey C Murray, Kenneth H Buetow, Moyra Smith, Leon Carlock, Aravinda Chakravarti, Robert F Ferrell, Lashitew Gedamu, Conrad Gilliam, Rita Shiang and Catherine R DeHaven

American journal of human genetics, Vol.42(3), pp.490-497

03/1988

PMCID: PMC1715141

PMID: 2894759

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Abstract

New RFLPs are described for INP10 and interleukin 2. The 55 pairwise genetic linkage relationships for these two loci and nine additional loci on the long arm of chromosome 4 (4q) are reported. Fifteen new linkages are established, and new data are added to the four previously reported linkages on 4q. Tight linkage of interleukin 2 (T-cell growth factor), epidermal growth factor, and alcohol dehydrogenase is described. Significant differences were observed between male and female recombination rates. The female rate was estimated to be 1.27 times the male rate. On the basis of these pairwise results, the order for the 11 loci is D4S35-GC-(ALB/AFP)-MT2P1-D4S1-INP10-ADH3-( EGF/IL2)-(FBB/FBA/FBG)-MNS. This preliminary order can serve as a starting point for more detailed multipoint analysis.

Details

Title: Subtitle: Pairwise linkage analysis of 11 loci on human chromosome 4
Creators: Jeffrey C Murray - Department of Pediatrics, University of Iowa 52242
Kenneth H Buetow - Fox Chase Cancer Center
Moyra Smith - University of California, Irvine
Leon Carlock - University of California, Irvine
Aravinda Chakravarti - University of Pittsburgh
Robert F Ferrell - University of Pittsburgh
Lashitew Gedamu - University of Calgary
Conrad Gilliam - Massachusetts General Hospital
Rita Shiang - University of Iowa
Catherine R DeHaven - University of Iowa
Resource Type: Journal article
Publication Details: American journal of human genetics, Vol.42(3), pp.490-497
PMID: 2894759
PMCID: PMC1715141
NLM abbreviation: Am J Hum Genet
ISSN: 0002-9297
eISSN: 1537-6605
Language: English
Date published: 03/1988
Academic Unit: Anatomy and Cell Biology; Stead Family Department of Pediatrics; Epidemiology; Pediatric Dentistry; Radiation Oncology; Craniofacial Anomalies Research Center; Dental Research
Record Identifier: 9984025588902771

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