Journal article
Palatogenesis and cutaneous repair: A two‐headed coin
Developmental dynamics, Vol.244(3), pp.289-310
03/2015
DOI: 10.1002/dvdy.24224
PMCID: PMC4344910
PMID: 25370680
Abstract
ABSTRACT
Background: The reparative mechanism that operates following post‐natal cutaneous injury is a fundamental survival function that requires a well‐orchestrated series of molecular and cellular events. At the end, the body will have closed the hole using processes like cellular proliferation, migration, differentiation and fusion. Results: These processes are similar to those occurring during embryogenesis and tissue morphogenesis. Palatogenesis, the formation of the palate from two independent palatal shelves growing towards each other and fusing, intuitively, shares many similarities with the closure of a cutaneous wound from the two migrating epithelial fronts. Conclusions: In this review, we summarize the current information on cutaneous development, wound healing, palatogenesis and orofacial clefting and propose that orofacial clefting and wound healing are conserved processes that share common pathways and gene regulatory networks. Developmental Dynamics 244:289–310, 2015. © 2014 Wiley Periodicals, Inc.
Key Findings
This manuscript highlights parallelisms at the cellular and molecular levels between the formation of the palate, the epidermis, the repair of the skin and cleft lip and palate.
It suggests that palatogenesis and cutaneous embryogenesis and repair share common gene regulatory networks.
Details
- Title: Subtitle
- Palatogenesis and cutaneous repair: A two‐headed coin
- Creators
- Leah C Biggs - Carver College of Medicine, The University of IowaSteven L Goudy - Vanderbilt Medical Center, Vanderbilt UniversityMartine Dunnwald - Carver College of Medicine, The University of Iowa
- Resource Type
- Journal article
- Publication Details
- Developmental dynamics, Vol.244(3), pp.289-310
- DOI
- 10.1002/dvdy.24224
- PMID
- 25370680
- PMCID
- PMC4344910
- NLM abbreviation
- Dev Dyn
- ISSN
- 1058-8388
- eISSN
- 1097-0177
- Number of pages
- 22
- Grant note
- National Institute of Health (AR061586)
- Language
- English
- Date published
- 03/2015
- Academic Unit
- Anatomy and Cell Biology; Craniofacial Anomalies Research Center
- Record Identifier
- 9984025347602771
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