Journal article
Palifermin (Kepivance) for the treatment of oral mucositis in patients with hematologic malignancies requiring hematopoietic stem cell support
Journal of oncology pharmacy practice, Vol.11(3), pp.121-125
09/2005
DOI: 10.1191/1078155205jp159oa
PMID: 16390600
Abstract
OBJECTIVETo provide a comprehensive review of the clinical use of the recombinant biological agent, palifermin, with particular reference to its use in its approved indication, oral mucositis resulting from high dose chemotherapy and radiation in patients with hematologic malignancies requiring hematopoietic stem cell support.DATA SOURCESA MEDLINE search was conducted using the terms 'palifermin' and 'Kepivance.' All data available from MEDLINE were reviewed. The reference lists from retrieved articles were reviewed and other relevant papers were identified.DATA SUMMARYKeratinocyte growth factor (KGF) is a growth factor that acts specifically on epithelial cells playing a role in proliferation, migration, and morphogenesis. Palifermin is a recombinant human form of KGF. Because of its ability to cause proliferation of the oral mucosa and to protect against mucosal injury, palifermin is a treatment option for patients who are at high risk for oral mucositis, specifically patients with hematological malignancies receiving stem cell transplantation (SCT). In a phase III study of these patients, the overall incidence of World Health Organization (WHO) grade 3 or 4 oral mucositis was significantly reduced in the palifermin group (palifermin = 63% versus placebo = 98%, P < 0.001). Among the patients who experienced WHO grade 3 or 4 oral mucositis the average duration of this grade of mucositis in the palifermin group was six days compared with nine days in the placebo group (P < 0.001). Common adverse effects of palifermin include pruritus, erythema, mouth and tongue disorders, and taste alterations.
Details
- Title: Subtitle
- Palifermin (Kepivance) for the treatment of oral mucositis in patients with hematologic malignancies requiring hematopoietic stem cell support
- Creators
- Michelle L RadtkeJill M Kolesar
- Resource Type
- Journal article
- Publication Details
- Journal of oncology pharmacy practice, Vol.11(3), pp.121-125
- DOI
- 10.1191/1078155205jp159oa
- PMID
- 16390600
- ISSN
- 1078-1552
- eISSN
- 1477-092X
- Language
- English
- Date published
- 09/2005
- Academic Unit
- Pharmacy; Pharmaceutical Sciences and Experimental Therapeutics
- Record Identifier
- 9984696542702771
Metrics
3 Record Views