Palladium-catalyzed cascade reaction for the synthesis of substituted isoindolines

Florence J Williams; Elizabeth R Jarvo

doi:10.1002/anie.201008160

Back

Palladium-catalyzed cascade reaction for the synthesis of substituted isoindolines

Journal article

Peer reviewed

Palladium-catalyzed cascade reaction for the synthesis of substituted isoindolines

Florence J Williams and Elizabeth R Jarvo

Angewandte Chemie (International ed.), Vol.50(19), pp.4459-4462

05/02/2011

DOI: 10.1002/anie.201008160

PMID: 21480447

View Online

Abstract

Arylate then cyclize: A palladium(II)-catalyzed cascade sequence has been developed to provide highly diastereomerically enriched cis-1-aryl-3-vinyl isoindolines (see scheme). The method uses commercially available aryl boronic acids and boroxine compounds containing a variety of electron-rich, -neutral, or -poor aromatic groups. Ts=4-toluenesulfonyl.

Indoles - chemical synthesis

Boronic Acids - chemistry

Catalysis

Stereoisomerism

Indoles - chemistry

Palladium - chemistry

Details

Title: Subtitle: Palladium-catalyzed cascade reaction for the synthesis of substituted isoindolines
Creators: Florence J Williams - Department of Chemistry, University of California, Irvine, Irvine, CA 92697, USA
Elizabeth R Jarvo
Resource Type: Journal article
Publication Details: Angewandte Chemie (International ed.), Vol.50(19), pp.4459-4462
Publisher: Germany
DOI: 10.1002/anie.201008160
PMID: 21480447
ISSN: 1433-7851
eISSN: 1521-3773
Language: English
Date published: 05/02/2011
Academic Unit: Iowa Neuroscience Institute; Chemistry
Record Identifier: 9984065469202771

Metrics

14 Record Views

51 Times Cited - Web of Science

See more details