Journal article
Palladium[0]-mediated aminospirocyclization of tertiary allylic sulfones. Stereospecific construction of the azabicyclic ring system of cephalotaxine
Tetrahedron letters, Vol.37(30), pp.5253-5256
1996
DOI: 10.1016/0040-4039(96)01112-4
Abstract
Tertiary allylic sulfones which bear a secondary aminopropyl moiety undergo smooth palladium [0]-mediated spirocyclization. The reaction proceeds via a π-allyl intermediate and the resultant azabicyclic product is formed with net retention of sulfone stereochemistry. The use of tetramethylguanidine as companion base is required for high yielding reactions.
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Details
- Title: Subtitle
- Palladium[0]-mediated aminospirocyclization of tertiary allylic sulfones. Stereospecific construction of the azabicyclic ring system of cephalotaxine
- Creators
- Zhendong Jin - Purdue University West LafayetteF.L Puchs - Purdue University West Lafayette
- Resource Type
- Journal article
- Publication Details
- Tetrahedron letters, Vol.37(30), pp.5253-5256
- Publisher
- Elsevier Ltd
- DOI
- 10.1016/0040-4039(96)01112-4
- ISSN
- 0040-4039
- eISSN
- 1873-3581
- Language
- English
- Date published
- 1996
- Academic Unit
- Pharmaceutical Sciences and Experimental Therapeutics; Medicinal and Natural Products Chemistry
- Record Identifier
- 9984366402002771
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