Palpebral fissure responses to topical adrenergic drugs

P M Munden; R H Kardon; C E Denison; K D Carter

doi:10.1016/S0002-9394(14)76775-3

Back

Palpebral fissure responses to topical adrenergic drugs

Journal article

Peer reviewed

Palpebral fissure responses to topical adrenergic drugs

P M Munden, R H Kardon, C E Denison and K D Carter

American journal of ophthalmology, Vol.111(6), pp.706-710

06/15/1991

DOI: 10.1016/S0002-9394(14)76775-3

PMID: 2039040

View Online

Abstract

We measured the magnitude and time course of the increase in palpebral fissure width in ten normal volunteers in response to direct-acting (2.5% phenylephrine, 1% apraclonidine) and indirect-acting (10% cocaine, 1% hydroxyamphetamine) topical adrenergic drugs given in one eye. The increase in the palpebral fissure width of the treated eye was compared to the width of the untreated, control eye during a period of 60 minutes after each drug was administered. The difference in fissure width (asymmetry) between the treated and untreated eyes increased significantly for all drugs during the three- to 60-minute time period after treatment. There was no significant difference in the maximum eyelid effect among the adrenergic drugs tested. The drugs exerted their maximum effect by 30 minutes in 39 of the 40 trials (97.5%). The direct-acting drugs tended to exert their effect more quickly than the indirect-acting drugs. Our results demonstrate the expected increase in palpebral fissure width in response to topical adrenergic drugs in normal eyes. This information will provide a basis for evaluating Müller's muscle and its sympathetic innervation in patients with blepharoptosis.

Sympathomimetics - administration & dosage

Humans

Amphetamine - pharmacology

Eyelids - drug effects

Sympathomimetics - pharmacology

Amphetamine - administration & dosage

Phenylephrine - administration & dosage

Clonidine - analogs & derivatives

Cocaine - administration & dosage

Cocaine - pharmacology

Phenylephrine - pharmacology

Time Factors

Clonidine - pharmacology

Clonidine - administration & dosage

Administration, Topical

Details

Title: Subtitle: Palpebral fissure responses to topical adrenergic drugs
Creators: P M Munden - Department of Ophthalmology, University of Iowa Hospitals and Clinics, Iowa City 52242
R H Kardon
C E Denison
K D Carter
Resource Type: Journal article
Publication Details: American journal of ophthalmology, Vol.111(6), pp.706-710
DOI: 10.1016/S0002-9394(14)76775-3
PMID: 2039040
NLM abbreviation: Am J Ophthalmol
ISSN: 0002-9394
eISSN: 1879-1891
Publisher: United States
Language: English
Date published: 06/15/1991
Academic Unit: Iowa Neuroscience Institute; Otolaryngology; Ophthalmology and Visual Sciences
Record Identifier: 9983980008002771

Metrics

18 Record Views

11 Times Cited - Web of Science

See more details