Journal article
Palpitations across the menopause transition in SWAN: trajectories, characteristics, and associations with subclinical cardiovascular disease
Menopause (New York, N.Y.), Vol.30(1), pp.18-27
01/01/2023
DOI: 10.1097/GME.0000000000002082
PMCID: PMC9797427
PMID: 36256921
Abstract
ObjectiveOur objectives were to identify trajectories of palpitations over the menopause transition, characterize them, and examine associations with subclinical cardiovascular disease (CVD).MethodsWe analyzed the following data from the multisite, multiethnic SWAN (Study of Women Across the Nation): reported palpitations occurrence over time; baseline sociodemographic, reproductive, medication, and health-related factors; and follow-up visit subclinical CVD (carotid atherosclerosis, vascular stiffness). Trajectories of palpitations (n = 3,276), their characteristics, and their associations with subclinical CVD (n = 1,559) were identified using group-based trajectory modeling and linear and logistic regression models.ResultsThree trajectories emerged: high probability of palpitations in perimenopause to early postmenopause diminishing in late postmenopause (15.9% of women), moderate probability of palpitations in perimenopause to early postmenopause diminishing in late postmenopause (34.3%), and sustained low probability of palpitations (49.8%). In the fully adjusted multivariable model, the high probability group had a more adverse reproductive and health-related profile at baseline (higher gravidity, early perimenopause, vasomotor symptoms, poorer overall health, higher depressive symptoms, higher perceived stress, greater sleep problems, higher blood pressure). In fully adjusted multivariable models, palpitation trajectories were not related to atherosclerosis or arterial stiffness.ConclusionsDistinct patterns of palpitations emerged, with a substantial portion of women having palpitations during the perimenopause and early postmenopause. Palpitations were not associated with subclinical CVD. Findings can help identify women at risk of palpitations during the menopause transition who may need symptom relief.
Details
- Title: Subtitle
- Palpitations across the menopause transition in SWAN: trajectories, characteristics, and associations with subclinical cardiovascular disease
- Creators
- Janet S. Carpenter - Indiana UniversityYamnia Cortes - University of North Carolina at Chapel HillJames E. Tisdale - Purdue University West LafayetteYing Sheng - Indiana UniversityElizabeth A. Jackson - University of Alabama at BirminghamEmma Barinas-Mitchell - University of PittsburghRebecca C. Thurston - University of Alabama at Birmingham
- Resource Type
- Journal article
- Publication Details
- Menopause (New York, N.Y.), Vol.30(1), pp.18-27
- DOI
- 10.1097/GME.0000000000002082
- PMID
- 36256921
- PMCID
- PMC9797427
- NLM abbreviation
- Menopause
- ISSN
- 1072-3714
- eISSN
- 1530-0374
- Publisher
- Lippincott Williams & Wilkins
- Number of pages
- 10
- Grant note
- UL1TR002529 / NIH, National Center for Advancing Translational Sciences, Clinical, and Translational Sciences Award National Institutes of Health (NIH); United States Department of Health & Human Services; National Institutes of Health (NIH) - USA Indiana Clinical and Translational Sciences Institute National Institute of Nursing Research (NINR); United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Nursing Research (NINR) U01NR004061; U01AG012505; U01AG012535; U01AG012531; U01AG012539; U01AG012546; U01AG012553; U01AG012554; U01AG012495; U19AG063720 / NIH Office of Research on Women's Health (ORWH); United States Department of Health & Human Services; National Institutes of Health (NIH) - USA US Department of Health and Human Services, through the National Institute on Aging (NIA) Indiana University Ethel Clarke Fellowship
- Language
- English
- Date published
- 01/01/2023
- Academic Unit
- Nursing
- Record Identifier
- 9984446418102771
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