Journal article
Pan-cancer Alterations of the MYC Oncogene and Its Proximal Network across the Cancer Genome Atlas
Cell systems, Vol.6(3), pp.282-300.e2
03/28/2018
DOI: 10.1016/j.cels.2018.03.003
PMCID: PMC5892207
PMID: 29596783
Abstract
Although the MYC oncogene has been implicated in cancer, a systematic assessment of alterations of MYC, related transcription factors, and co-regulatory proteins, forming the proximal MYC network (PMN), across human cancers is lacking. Using computational approaches, we define genomic and proteomic features associated with MYC and the PMN across the 33 cancers of The Cancer Genome Atlas. Pan-cancer, 28% of all samples had at least one of the MYC paralogs amplified. In contrast, the MYC antagonists MGA and MNT were the most frequently mutated or deleted members, proposing a role as tumor suppressors. MYC alterations were mutually exclusive with PIK3CA, PTEN, APC, or BRAF alterations, suggesting that MYC is a distinct oncogenic driver. Expression analysis revealed MYC-associated pathways in tumor subtypes, such as immune response and growth factor signaling; chromatin, translation, and DNA replication/repair were conserved pan-cancer. This analysis reveals insights into MYC biology and is a reference for biomarkers and therapeutics for cancers with alterations of MYC or the PMN.
Details
- Title: Subtitle
- Pan-cancer Alterations of the MYC Oncogene and Its Proximal Network across the Cancer Genome Atlas
- Creators
- Franz X Schaub - Cure First, Seattle, WA, USA; SEngine Precision Medicine, Seattle, WA, USAVarsha Dhankani - SEngine Precision Medicine, Seattle, WA, USAAshton C Berger - Massachusetts Institute of TechnologyMihir Trivedi - SEngine Precision Medicine, Seattle, WA, USAAnne B Richardson - SEngine Precision Medicine, Seattle, WA, USAReid Shaw - SEngine Precision Medicine, Seattle, WA, USAWei Zhao - The University of Texas MD Anderson Cancer CenterXiaoyang Zhang - Harvard UniversityAndrea Ventura - Memorial Sloan Kettering Cancer CenterYuexin Liu - The University of Texas MD Anderson Cancer CenterDonald E Ayer - Huntsman Cancer InstitutePeter J Hurlin - Oregon Health & Science UniversityAndrew D Cherniack - Harvard UniversityRobert N Eisenman - Cancer Research CenterBrady Bernard - Providence Health & ServicesCarla Grandori - Cure First, Seattle, WA, USA; SEngine Precision Medicine, Seattle, WA, USA. Electronic address: carlagrandori@curefirst.org
- Contributors
- Cancer Genome Atlas Network (Contributor)Deqin Ma (Contributor) - University of Iowa, PathologyMohammed M Milhem (Contributor) - University of Iowa, Internal MedicineAaron D Bossler (Contributor) - University of Iowa, Pathology
- Resource Type
- Journal article
- Publication Details
- Cell systems, Vol.6(3), pp.282-300.e2
- DOI
- 10.1016/j.cels.2018.03.003
- PMID
- 29596783
- PMCID
- PMC5892207
- NLM abbreviation
- Cell Syst
- ISSN
- 2405-4712
- eISSN
- 2405-4720
- Grant note
- U24 CA143843 / NCI NIH HHS R01 CA214428 / NCI NIH HHS U24 CA210957 / NCI NIH HHS R01 CA149707 / NCI NIH HHS U54 HG003079 / NHGRI NIH HHS P30 CA016672 / NCI NIH HHS R01 CA057138 / NCI NIH HHS U24 CA143883 / NCI NIH HHS U24 CA210990 / NCI NIH HHS U24 CA143799 / NCI NIH HHS U01 CA176303 / NCI NIH HHS U01 CA217883 / NCI NIH HHS R50 CA221675 / NCI NIH HHS U24 CA143867 / NCI NIH HHS U24 CA143858 / NCI NIH HHS U24 CA143882 / NCI NIH HHS U54 HG003067 / NHGRI NIH HHS U24 CA143845 / NCI NIH HHS U24 CA143835 / NCI NIH HHS U54 HG003273 / NHGRI NIH HHS U24 CA143840 / NCI NIH HHS U24 CA144025 / NCI NIH HHS U24 CA143866 / NCI NIH HHS U24 CA210950 / NCI NIH HHS U24 CA210949 / NCI NIH HHS R01 CA163722 / NCI NIH HHS U24 CA143848 / NCI NIH HHS
- Language
- English
- Date published
- 03/28/2018
- Academic Unit
- Hematology, Oncology, and Blood & Marrow Transplantation; Pathology; Internal Medicine
- Record Identifier
- 9984185166302771
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