Journal article
Pancreatic Neuroendocrine Tumors: Molecular Mechanisms and Therapeutic Targets
Cancers, Vol.13(20), p.5117
10/01/2021
DOI: 10.3390/cancers13205117
PMCID: PMC8533967
PMID: 34680266
Abstract
Simple Summary:& nbsp;Pancreatic neuroendocrine tumors (pNETs) are rare, indolent cancers whose causation is only partly understood. An increasing number of studies have uncovered molecular changes associated with pNETs, helping to identify common disease mechanisms. This knowledge has guided current pNET therapies that can effectively slow progression of the disease. However, tumors often become resistant to available therapies, necessitating a deeper understanding of mechanisms driving disease progression in order to develop new treatments. Here, we provide a comprehensive review of pNET-associated molecular alterations and existing pNET models to illustrate potential areas for advancement in research and therapy.
& nbsp;
Pancreatic neuroendocrine tumors (pNETs) are unique, slow-growing malignancies whose molecular pathogenesis is incompletely understood. With rising incidence of pNETs over the last four decades, larger and more comprehensive 'omic' analyses of patient tumors have led to a clearer picture of the pNET genomic landscape and transcriptional profiles for both primary and metastatic lesions. In pNET patients with advanced disease, those insights have guided the use of targeted therapies that inhibit activated mTOR and receptor tyrosine kinase (RTK) pathways or stimulate somatostatin receptor signaling. Such treatments have significantly benefited patients, but intrinsic or acquired drug resistance in the tumors remains a major problem that leaves few to no effective treatment options for advanced cases. This demands a better understanding of essential molecular and biological events underlying pNET growth, metastasis, and drug resistance. This review examines the known molecular alterations associated with pNET pathogenesis, identifying which changes may be drivers of the disease and, as such, relevant therapeutic targets. We also highlight areas that warrant further investigation at the biological level and discuss available model systems for pNET research. The paucity of pNET models has hampered research efforts over the years, although recently developed cell line, animal, patient-derived xenograft, and patient-derived organoid models have significantly expanded the available platforms for pNET investigations. Advancements in pNET research and understanding are expected to guide improved patient treatments.
Details
- Title: Subtitle
- Pancreatic Neuroendocrine Tumors: Molecular Mechanisms and Therapeutic Targets
- Creators
- Chandra K. Maharjan - Roy J. and Lucille A. Carver College of MedicinePo Hien Ear - Roy J. and Lucille A. Carver College of MedicineCatherine G. Tran - Roy J. and Lucille A. Carver College of MedicineJames R. Howe - Roy J. and Lucille A. Carver College of MedicineChandrikha Chandrasekharan - Roy J. and Lucille A. Carver College of MedicineDawn E. Quelle - Roy J. and Lucille A. Carver College of Medicine
- Resource Type
- Journal article
- Publication Details
- Cancers, Vol.13(20), p.5117
- DOI
- 10.3390/cancers13205117
- PMID
- 34680266
- PMCID
- PMC8533967
- NLM abbreviation
- Cancers (Basel)
- ISSN
- 2072-6694
- eISSN
- 2072-6694
- Publisher
- Mdpi
- Number of pages
- 51
- Grant note
- R01 CA260200; P50 CA174521; P30 CA086862 / National Cancer Institute; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI)
- Language
- English
- Date published
- 10/01/2021
- Academic Unit
- Hematology, Oncology, and Blood & Marrow Transplantation; Pathology; Surgery; Neuroscience and Pharmacology; Internal Medicine
- Record Identifier
- 9984303747002771
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