Pancreatic Pain-Knowledge Gaps and Research Opportunities in Children and Adults Summary of a National Institute of Diabetes and Digestive and Kidney Diseases Workshop

Uc Aliye; Dana K. Andersen; A. Vania Apkarian; Melena D. Bellin; Luana Colloca; Asbjorn M. Drewes; Ellyn K. Dunbar; Christopher E. Forsmark; Marc T. Goodman; Leonardo Kapural; George F. Koob; Tonya M. Palermo; Stephen J. Pandol; Pankaj Pasricha; Anna E. Phillips; Daniele Piomelli; Jami L. Saloman; Sarah Jane Schwarzenberg; Vikesh K. Singh; Gwendolyn Sowa; Thomas Strouse; Glenn J. Treisman; John A. Windsor; Dhiraj Yadav

doi:10.1097/MPA.0000000000001899

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Pancreatic Pain-Knowledge Gaps and Research Opportunities in Children and Adults Summary of a National Institute of Diabetes and Digestive and Kidney Diseases Workshop

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Pancreatic Pain-Knowledge Gaps and Research Opportunities in Children and Adults Summary of a National Institute of Diabetes and Digestive and Kidney Diseases Workshop

Uc Aliye, Dana K. Andersen, A. Vania Apkarian, Melena D. Bellin, Luana Colloca, Asbjorn M. Drewes, Ellyn K. Dunbar, Christopher E. Forsmark, Marc T. Goodman, Leonardo Kapural, …

Pancreas, Vol.50(7), pp.906-915

08/01/2021

DOI: 10.1097/MPA.0000000000001899

PMCID: PMC10273134

PMID: 34643606

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https://pmc.ncbi.nlm.nih.gov/articles/PMC10273134/pdf/nihms-1881186.pdfView

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Abstract

A workshop was sponsored by the National Institute of Diabetes and Digestive and Kidney Diseases to focus on research gaps and opportunities in pancreatic pain. The event was held on July 21, 2021, and structured into 4 sessions: (1) pathophysiology; (2) biomarkers, mediators, and pharmacology of pain; (3) pain assessment; and (4) pain treatment challenges and opportunities. The current state of knowledge was reviewed; many knowledge gaps and research needs were identified that require further investigation. Common themes included the need to better understand the underlying mechanisms of pain in pancreatic diseases, the relationship of visceral neural pathways and central pain centers, the role of behavioral factors and disorders on the perception of pain, and differences in pain perception and processes in children when compared with adults. In addition, the role of genetic risk factors for pain and the mechanisms and role of placebos in pain treatment were discussed. Methods of pain assessment including quantitative sensory testing were examined, as well as the process of central sensitization of pain. Finally, newer approaches to pain management including cognitive behavioral therapy, nerve stimulation, experimental (nonopioid) drugs, and cannabinoid compounds were covered.

Gastroenterology & Hepatology

Life Sciences & Biomedicine

Science & Technology

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Title: Subtitle: Pancreatic Pain-Knowledge Gaps and Research Opportunities in Children and Adults Summary of a National Institute of Diabetes and Digestive and Kidney Diseases Workshop
Creators: Uc Aliye - Univ Iowa, Div Gastroenterol Hepatol Pancreatol & Nutr, Stead Family Dept Pediat, Iowa City, IA 52240 USA
Dana K. Andersen - National Institute of Diabetes and Digestive and Kidney Diseases
A. Vania Apkarian - Northwestern University
Melena D. Bellin - University of Minnesota
Luana Colloca - University of Maryland, Baltimore
Asbjorn M. Drewes - Aalborg Univ Hosp, Dept Gastroenterol & Hepatol, Aalborg, Denmark
Ellyn K. Dunbar - University of Pittsburgh
Christopher E. Forsmark - Cedars Sinai Med Ctr, Samuel Oschin Canc Ctr, Canc Prevent & Control Program, Los Angeles, CA 90048 USA
Marc T. Goodman - Cedars-Sinai Medical Center
Leonardo Kapural - Carolinas Pain Institute
George F. Koob - National Institute on Alcohol Abuse and Alcoholism
Tonya M. Palermo - Seattle Children's Hospital
Stephen J. Pandol - Cedars-Sinai Medical Center
Pankaj Pasricha - Johns Hopkins Medicine
Anna E. Phillips - Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine.
Daniele Piomelli - University of California, Irvine
Jami L. Saloman - Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine.
Sarah Jane Schwarzenberg - Division of Pediatric Gastroenterology, Hepatology and Nutrition, University of Minnesota Masonic Children's Hospital, Minneapolis, MN
Vikesh K. Singh - Johns Hopkins Medicine
Gwendolyn Sowa - University of Pittsburgh
Thomas Strouse - Department of Psychiatry and Biobehavioral Sciences David Geffen School of Medicine at UCLA Los Angeles CA.
Glenn J. Treisman - Johns Hopkins Medicine
John A. Windsor - University of Auckland, Faculty of Medical and Health Sciences
Dhiraj Yadav - Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine.
Resource Type: Journal article
Publication Details: Pancreas, Vol.50(7), pp.906-915
DOI: 10.1097/MPA.0000000000001899
PMID: 34643606
PMCID: PMC10273134
NLM abbreviation: Pancreas
ISSN: 0885-3177
eISSN: 1536-4828
Publisher: Lippincott Williams & Wilkins
Number of pages: 10
Grant note: National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK)
Language: English
Date published: 08/01/2021
Academic Unit: Stead Family Department of Pediatrics; Radiation Oncology; Gastroenterology, Hepatology, Pancreatology, and Nutrition
Record Identifier: 9984313081702771

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