Journal article
Pancreatic cancer and autoimmune diseases: An association sustained by computational and epidemiological case-control approaches
International journal of cancer, Vol.144(7), pp.1540-1549
04/01/2019
DOI: 10.1002/ijc.31866
PMID: 30229903
Abstract
Deciphering the underlying genetic basis behind pancreatic cancer (PC) and its associated multimorbidities will enhance our knowledge toward PC control. The study investigated the common genetic background of PC and different morbidities through a computational approach and further evaluated the less explored association between PC and autoimmune diseases (AIDs) through an epidemiological analysis. Gene-disease associations (GDAs) of 26 morbidities of interest and PC were obtained using the DisGeNET public discovery platform. The association between AIDs and PC pointed by the computational analysis was confirmed through multivariable logistic regression models in the PanGen European case-control study population of 1,705 PC cases and 1,084 controls. Fifteen morbidities shared at least one gene with PC in the DisGeNET database. Based on common genes, several AIDs were genetically associated with PC pointing to a potential link between them. An epidemiologic analysis confirmed that having any of the nine AIDs studied was significantly associated with a reduced risk of PC (Odds Ratio (OR) = 0.74, 95% confidence interval (CI) 0.58-0.93) which decreased in subjects having ≥2 AIDs (OR = 0.39, 95%CI 0.21-0.73). In independent analyses, polymyalgia rheumatica, and rheumatoid arthritis were significantly associated with low PC risk (OR = 0.40, 95%CI 0.19-0.89, and OR = 0.73, 95%CI 0.53-1.00, respectively). Several inflammatory-related morbidities shared a common genetic component with PC based on public databases. These molecular links could shed light into the molecular mechanisms underlying PC development and simultaneously generate novel hypotheses. In our study, we report sound findings pointing to an association between AIDs and a reduced risk of PC.
Details
- Title: Subtitle
- Pancreatic cancer and autoimmune diseases: An association sustained by computational and epidemiological case-control approaches
- Creators
- Paulina Gomez-Rubio - Centro de Investigación Biomédica en Red en Oncología (CIBERONC), Enfermedades Hepáticas y Digestivas (CIBERHD), and Epidemiología y Salud Pública (CIBERESP), Barcelona, SpainJanet Piñero - Research Program on Biomedical Informatics (GRIB), Hospital del Mar Research Institute (IMIM), Universidad Pompeu Fabra (UPF), Barcelona, SpainEsther Molina-Montes - Centro de Investigación Biomédica en Red en Oncología (CIBERONC), Enfermedades Hepáticas y Digestivas (CIBERHD), and Epidemiología y Salud Pública (CIBERESP), Barcelona, SpainAlba Gutiérrez-Sacristán - Research Program on Biomedical Informatics (GRIB), Hospital del Mar Research Institute (IMIM), Universidad Pompeu Fabra (UPF), Barcelona, SpainMirari Marquez - Centro de Investigación Biomédica en Red en Oncología (CIBERONC), Enfermedades Hepáticas y Digestivas (CIBERHD), and Epidemiología y Salud Pública (CIBERESP), Barcelona, SpainMarta Rava - Centro de Investigación Biomédica en Red en Oncología (CIBERONC), Enfermedades Hepáticas y Digestivas (CIBERHD), and Epidemiología y Salud Pública (CIBERESP), Barcelona, SpainChristoph W Michalski - Department of Surgery, University of Heidelberg, Heidelberg, GermanyAntoni Farré - Department of Gastroenterology, Hospital de la Santa Creu i Sant Pau, Barcelona, SpainXavier Molero - Universitat Auntònoma de Barcelona, Campus de la UAB, Barcelona, SpainMatthias Löhr - Department of Clinical Science, Intervention and Technology (CLINTEC), Karolinska Institutet and University Hospital, Stockholm, SwedenJosé Perea - Department of Surgery, University Hospital 12 de Octubre, Madrid, SpainWilliam Greenhalf - Department of Molecular and Clinical Cancer Medicine, The Royal Liverpool University Hospital, Liverpool, United KingdomMichael O'Rorke - Centre for Public Health, Queen's University Belfast, Belfast, United KingdomAdonina Tardón - Department of Medicine, Instituto Universitario de Oncología del Principado de Asturias, Oviedo, SpainThomas Gress - Department of Gastroenterology, University Hospital of Giessen and Marburg, Marburg, GermanyVictor M Barberá - Laboratorio de Genética Molecular, Hospital General Universitario de Elche, Elche, SpainTatjana Crnogorac-Jurcevic - Centre for Molecular Oncology, John Vane Science Centre, Barts Cancer Institute, Queen Mary University of London, London, United KingdomLuís Muñoz-Bellvís - General and Digestive Surgery Department, Hospital Universitario de Salamanca, Salamanca, SpainEnrique Domínguez-Muñoz - Department of Gastroenterology, Hospital Clínico Universitario de Santiago de Compostela, Santiago de Compostela, SpainJoaquim Balsells - Universitat Auntònoma de Barcelona, Campus de la UAB, Barcelona, SpainEithne Costello - Department of Molecular and Clinical Cancer Medicine, The Royal Liverpool University Hospital, Liverpool, United KingdomJingru Yu - Department of Clinical Science, Intervention and Technology (CLINTEC), Karolinska Institutet and University Hospital, Stockholm, SwedenMar Iglesias - Department of Gastroenterology, Hospital del Mar/Parc de Salut Mar, Barcelona, SpainLucas Ilzarbe - Department of Gastroenterology, Hospital del Mar/Parc de Salut Mar, Barcelona, SpainJörg Kleeff - Department of Visceral, Vascular and Endocrine Surgery, Martin-Luther-University Halle-Wittenberg, Halle, (Saale), GermanyBo Kong - Department of Surgery, Technical University of Munich, Munich, GermanyJosefina Mora - Department of Gastroenterology, Hospital de la Santa Creu i Sant Pau, Barcelona, SpainLiam Murray - Centre for Public Health, Queen's University Belfast, Belfast, United KingdomDamian O'Driscoll - Cancer Data Registrars, National Cancer Registry Ireland, Cork, IrelandIgnasi Poves - Department of Gastroenterology, Hospital del Mar/Parc de Salut Mar, Barcelona, SpainRita T Lawlor - ARC-Net Centre for Applied Research on Cancer, Department of Pathology and Diagnostics, University Hospital Trust of Verona, Verona, ItalyWeimin Ye - Department of Medical Epidemiology and Biostatistics, Karolinska Institutet and University Hospital, SwedenManuel Hidalgo - Rosenberg Clinical Cancer Center, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MAAldo Scarpa - ARC-Net Centre for Applied Research on Cancer, Department of Pathology and Diagnostics, University Hospital Trust of Verona, Verona, ItalyLinda Sharp - Institute of Health and Society, Newcastle University, Newcastle upon Tyne, United KingdomAlfredo Carrato - Department of Oncology, Hospital Ramón y Cajal, Madrid, SpainFrancisco X Real - Departament de Ciències Experimentals i de la Salut, Universitat Pompeu Fabra, Barcelona, SpainLaura I Furlong - Research Program on Biomedical Informatics (GRIB), Hospital del Mar Research Institute (IMIM), Universidad Pompeu Fabra (UPF), Barcelona, SpainNúria Malats - Centro de Investigación Biomédica en Red en Oncología (CIBERONC), Enfermedades Hepáticas y Digestivas (CIBERHD), and Epidemiología y Salud Pública (CIBERESP), Barcelona, SpainPanGenEU Study Investigators
- Resource Type
- Journal article
- Publication Details
- International journal of cancer, Vol.144(7), pp.1540-1549
- DOI
- 10.1002/ijc.31866
- PMID
- 30229903
- ISSN
- 0020-7136
- eISSN
- 1097-0215
- Grant note
- 634143 MedBioinformatics676559 Elixir-Excelerate / EU H2020 Programme 2014-2020 #018771-MOLDIAG-PACA / EU-6FP Integrated Project #SLL20130022 / Swedish ALF #PI0902102#PI11/01542#PI12/ 00815#PI12/01635#PI13/ 00082CP10/00524PI15/01573 / The work was partially supported by Fondo de Investigaciones Sanitarias (FIS), Instituto de Salud Carlos III-FEDER, Spain #GEN2001-4748-c05-03 / Acción Especial de Genómica, Spain Cancer Focus Northern Ireland and Department for Employment and Learning #256974-EPC-TM-Net#259737-CANCERALIA#602783- Cam-Pac / EU-FP7-HEALTH FIMPCUP_J33G13000210001 / Italian Ministry of Health #RD12/0036/0050#RD12/0036/ 0073(#RD12/0036/0034 / Red Temática de Investigación Cooperativa en Cáncer, Spain WCR #15-0391 / World Cancer Research Fund Italian Foundation for Cancer Research (FIRC)
- Language
- English
- Date published
- 04/01/2019
- Academic Unit
- Epidemiology; Pathology
- Record Identifier
- 9984214682702771
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